Effect of Continuous Positive Airway Pressure Treatment on the Arteriole-to-Venule Ratio in Patients With Nonproliferative Diabetic Retinopathy and Obstructive Sleep Apnea: A Randomized Trial.
Ophthalmic Surg Lasers Imaging Retina
; : 1-8, 2024 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-39254495
ABSTRACT
BACKGROUND AND OBJECTIVE:
This study aimed to assess the effect of continuous positive airway pressure (CPAP) on the arteriolar-to-venular ratio (AVR) in patients with diabetic retinopathy (DR) and obstructive sleep apnea (OSA). PATIENTS ANDMETHODS:
A prospective, randomized, unblinded, and controlled clinical trial with parallel groups was performed. From a base of 138 patients, 83 were randomized to either CPAP or control. Nonstereoscopic 35º photographs were processed with Sirius software.RESULTS:
The intention-to-treat analysis showed no differences in AVR, although the arteriolar diameter increased from baseline in the CPAP group. Per-protocol analysis showed a 12-month increase in AVR (P = 0.035) and arteriolar diameter (P = 0.033) in CPAP versus control group. The venular diameter showed a nonstatistically significant reduction.CONCLUSIONS:
CPAP is a potentially novel treatment for individuals with DR and concomitant OSA, improving the retinopathy status, reversing the arteriolar narrowing, and therefore increasing the AVR, tending to reduce the venular diameter. [Ophthalmic Surg Lasers Imaging Retina 2024;55XX-XX.].
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Ophthalmic Surg Lasers Imaging Retina
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Estados Unidos