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Progress in nanoparticle-based electrochemical biosensors for hormone detection.
Rossi, Francesco; Trakoolwilaiwan, Thithawat; Gigli, Valeria; Tortolini, Cristina; Lenzi, Andrea; Isidori, Andrea Maria; Thanh, Nguyen Thi Kim; Antiochia, Riccarda.
Afiliación
  • Rossi F; ICCOM-CNR, Polo Scientifico, Via Madonna del piano 10, Sesto Fiorentino, FI, 50019, Italy.
  • Trakoolwilaiwan T; Biophysics Group, Department of Physics and Astronomy, University College London, Gower Street, London WC1E 6BT, UK.
  • Gigli V; UCL Healthcare Biomagnetics and Nanomaterials Laboratories, 21 Albemarle Street, London W1S 4BS, UK. ntk.thanh@ucl.ac.uk.
  • Tortolini C; National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, Thailand.
  • Lenzi A; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
  • Isidori AM; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
  • Thanh NTK; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
  • Antiochia R; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Nanoscale ; 2024 Sep 10.
Article en En | MEDLINE | ID: mdl-39254475
ABSTRACT
Hormones are chemical messengers that regulate a wide range of physiological processes including metabolism, development, growth, reproduction and mood. The concentration of hormones that orchestrate the numerous bodily functions is very low (1 nM or less). Efforts have been made to develop highly sensitive tools to detect them. This review represents a critical comparison between different types of nanoparticle-based electrochemical biosensors for the detection of various hormones, namely cortisol, sex hormones (estradiol, progesterone, testosterone), insulin, thyroid-stimulating hormone (TSH) and growth hormone (GH). The electrochemical biosensors investigated for each hormone are first divided on the basis of the biological fluid tested for their detection, and successively on the basis of the electrochemical transducer utilized in the device (voltammetric or impedimetric). Focus is placed on the nanoparticles employed and the successive electrode modification developed in order to improve detection sensitivity and specificity and biosensor stability. Limit of detection (LOD), linear range, reproducibility and possibility of regeneration for continuous reuse are also investigated and compared. The review also addresses the recent trends in the development of wearable biosensors and point-of-care testing for hormone detection in clinical diagnostics useful for endocrinology research, and the future perspectives regarding the integration of nanomaterials, microfluidics, near field communication (NFC) technology and portable devices.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nanoscale Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nanoscale Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido