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Cardiac magnetic resonance imaging-derived pathophysiology and prognosis of diabetes mellitus with acute myocardial infarction after revascularization: a prospective cohort study.
Li, Miaonan; Wang, Jun; Ding, Siyu; Ding, Bin; Oketunbi, Temilola J; Song, Xilong; Li, Yao; Niu, Qilin; Shi, Xiaojun; Gao, Dasheng; Hu, Sigan; Jin, Guoxi; Wang, Hongju.
Afiliación
  • Li M; Department of Cardiovascular Disease, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
  • Wang J; Department of Cardiovascular Disease, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
  • Ding S; Department of Cardiovascular Disease, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
  • Ding B; Department of Cardiovascular Disease, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
  • Oketunbi TJ; Department of Cardiovascular Disease, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
  • Song X; Department of Cardiovascular Disease, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
  • Li Y; Department of Cardiovascular Disease, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
  • Niu Q; Department of Radiology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
  • Shi X; Department of Cardiovascular Disease, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
  • Gao D; Department of Cardiovascular Disease, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
  • Hu S; Department of Cardiovascular Disease, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
  • Jin G; Department of Endocrine, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
  • Wang H; Department of Cardiovascular Disease, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Ann Med ; 56(1): 2399751, 2024 Dec.
Article en En | MEDLINE | ID: mdl-39253848
ABSTRACT

BACKGROUND:

Little is known about the underlying factors contributing to unfavourable clinical outcomes in patients with diabetes mellitus (DM) complicated by new-onset acute myocardial infarction (AMI). The aim of this study was to investigate the impact of DM on the pathophysiologic features and prognosis of patients with new-onset AMI following successful revascularization by utilizing cardiac magnetic resonance (CMR).

METHODS:

Consecutive patients diagnosed with new-onset AMI between June 2022 and January 2024 were included. All patients underwent culprit vessel revascularization upon admission and CMR imaging 3-7 days later. The primary clinical endpoint of this study was the occurrence of major adverse cardiac and cerebrovascular events (MACCEs), for which the average follow-up was 10 months.

RESULTS:

A total of 72 patients were divided into a DM group (n = 23) and a non-DM group (n = 49). Multivariate logistic regression analysis revealed that DM was an independent risk factor for the occurrence of microvascular obstruction. Multivariate linear regression analysis found that DM was the influencing factor of global radial strain (B = -4.107, t = -2.328, p = 0.023), while fasting blood glucose influenced infarct segment myocardial radial strain (B = -0.622, t = -2.032, p = 0.046). DM independently contributed to the risk of MACCEs following successful revascularization in patients with AMI (p < 0.05).

CONCLUSION:

Comprehensive phenotypic characterization of myocardial injury and microcirculatory status could enable reliable identification of high-risk MACCEs in DM patients with new-onset AMI following successful revascularization.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infarto del Miocardio Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Med Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infarto del Miocardio Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Med Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido