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Relationship Between IL-10 Single Nucleotide Polymorphisms (rs1800871, rs1800872, and rs1800896) and the Severity of COVID-19.
Azadinejad, Hossein; Feizollahi, Parisa; Rezaeimanesh, Alireza; Salari, Farhad; Gorgin Karaji, Ali.
Afiliación
  • Azadinejad H; Student Research Committee, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Feizollahi P; Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Rezaeimanesh A; Department of Immunology, School of Medicine, Tarbiat Modares University of Medical Science, Tehran, Iran.
  • Salari F; Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Gorgin Karaji A; Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Genet Test Mol Biomarkers ; 2024 Sep 10.
Article en En | MEDLINE | ID: mdl-39253838
ABSTRACT

Background:

Interleukin-10 (IL-10) is an anti-inflammatory cytokine whose levels are elevated in patients with severe COVID-19. IL-10 polymorphisms may play a role in increasing IL-10 levels and the severity of COVID-19. This study aimed to investigate the relationship between IL-10 single nucleotide polymorphisms (SNPs) (rs1800896 [-1082 C < T], rs1800871 [-819 A > G], and rs1800872 [-592 T > G]) and the severity of COVID-19 in patients from Kermanshah Province, Iran.

Methods:

A total of 150 patients with mild COVID-19 (84 men and 66 women aged 40.1 ± 12.44 years) and 143 patients with severe COVID-19 (76 men and 67 women aged 61.04 ± 15.65 years) participated in this study. Blood samples were collected from the patients, DNA was extracted, and the genotype of each SNPs was determined using the polymerase chain reaction-restriction fragment length polymorphism method.

Result:

The results of this study did not show a significant relationship between the genotypes of the three studied SNPs and the severity of COVID-19 (p > 0.05).

Conclusion:

According to our findings, these SNPs were not associated with COVID-19 severity in patients in Kermanshah.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Genet Test Mol Biomarkers Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Genet Test Mol Biomarkers Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos