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Harnessing the potential of mesenchymal stem cells-derived exosomes in degenerative diseases.
Liao, Hsiu-Jung; Yang, Yi-Ping; Liu, Yu-Hao; Tseng, Huan-Chin; Huo, Teh-Ia; Chiou, Shih-Hwa; Chang, Chih-Hung.
Afiliación
  • Liao HJ; Department of Medical Research, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
  • Yang YP; Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.
  • Liu YH; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
  • Tseng HC; School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan.
  • Huo TI; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
  • Chiou SH; Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, Taipei, Taiwan.
  • Chang CH; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
Regen Ther ; 26: 599-610, 2024 Jun.
Article en En | MEDLINE | ID: mdl-39253597
ABSTRACT
Mesenchymal stem cells (MSCs) have gained attention as a promising therapeutic approach in both preclinical and clinical osteoarthritis (OA) settings. Various joint cell types, such as chondrocytes, synovial fibroblasts, osteoblasts, and tenocytes, can produce and release extracellular vesicles (EVs), which subsequently influence the biological activities of recipient cells. Recently, extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) have shown the potential to modulate various physiological and pathological processes through the modulation of cellular differentiation, immune responses, and tissue repair. This review explores the roles and therapeutic potential of MSC-EVs in OA and rheumatoid arthritis, cardiovascular disease, age-related macular degeneration, Alzheimer's disease, and other degenerative diseases. Notably, we provide a comprehensive summary of exosome biogenesis, microRNA composition, mechanisms of intercellular transfer, and their evolving role in the highlight of exosome-based treatments in both preclinical and clinical avenues.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Regen Ther Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Regen Ther Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Países Bajos