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Complete Blood Cell Count-Derived Inflammation Biomarkers and the Need for Laser Capsulotomy Due to Posterior Capsule Opacification Following Cataract Surgery.
Uzun, Feyzahan; Aydin, Emre; Akgöz, Hasan; Aslan, Mehmet Gökhan.
Afiliación
  • Uzun F; Recep Tayyip Erdogan University, School of Medicine, Department of Ophthalmology, Rize, Turkey.
  • Aydin E; Recep Tayyip Erdogan University, School of Medicine, Department of Ophthalmology, Rize, Turkey.
  • Akgöz H; Recep Tayyip Erdogan University, School of Medicine, Department of Ophthalmology, Rize, Turkey.
  • Aslan MG; Recep Tayyip Erdogan University, School of Medicine, Department of Ophthalmology, Rize, Turkey.
J Inflamm Res ; 17: 6075-6082, 2024.
Article en En | MEDLINE | ID: mdl-39253563
ABSTRACT

Background:

Inflammation plays a significant role in the proliferation, migration, and differentiation of lens epithelial cells after cataract surgery, clinically manifested as posterior capsule opacification (PCO). This condition is typically treated with neodymium yttrium-aluminum-garnet (NdYAG) laser capsulotomy. Our objective is to evaluate the association between blood-derived inflammatory markers and the development of clinically significant PCO necessitating treatment with laser capsulotomy. Materials and

Methods:

We conducted a retrospective review of charts for all patients who underwent NdYAG laser capsulotomy in our department between January 2021 and December 2022. The study included 70 patients who diagnosed with clinically significant PCO requiring treatment with NdYAG laser capsulotomy following cataract surgery, as well as 70 pseudophakic controls with no signs of PCO. Complete blood cell count parameters were obtained from medical records and the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) were calculated.

Results:

The mean age of the NdYAG laser capsulotomy and control group was 71.83±8.46 and 72.27±9.98 years, respectively. The preoperative NLR scores for the NdYAG laser capsulotomy group (mean rank = 34.43) were statistically significantly higher than those of the control group (mean rank = 25.41) (p = 0.044). However, after adjusting for preoperative measurements, no statistically significant differences were observed between the groups for the other parameters.

Conclusion:

Preoperative NLR scores were higher in patients who developed clinically significant PCO requiring treatment with NdYAG laser capsulotomy. This finding suggests that patients with elevated systemic inflammation may be at an increased risk of developing PCO following cataract surgery. Further research is needed to evaluate the role of systemic inflammation in the pathogenesis of PCO.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Inflamm Res Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Nueva Zelanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Inflamm Res Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Nueva Zelanda