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Natural Flavonoid-Derived Enzyme Mimics DHKNase Balance the Two-Edged Reactive Oxygen Species Function for Wound Healing and Inflammatory Bowel Disease Therapy.
Feng, Guangfu; Zhang, Huaizu; Liu, Huipeng; Zhang, Xiaoyan; Jiang, Hongmei; Liao, Sijie; Luo, Xingyu; Yao, Hao; Xiang, Bo; Liu, Shiyu; Zhang, Jiali; Zhang, Jiaheng; Fang, Jun.
Afiliación
  • Feng G; School of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan 410128, P.R. China.
  • Zhang H; School of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan 410128, P.R. China.
  • Liu H; School of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan 410128, P.R. China.
  • Zhang X; College of Life Science, Shihezi University, Shihezi, Xinjiang 832003, P.R. China.
  • Jiang H; School of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan 410128, P.R. China.
  • Liao S; School of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan 410128, P.R. China.
  • Luo X; School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, P.R. China.
  • Yao H; Changsha IMADEK Intelligent Technology Co. Ltd., Changsha, Hunan 410081, P.R. China.
  • Xiang B; School of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan 410128, P.R. China.
  • Liu S; School of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan 410128, P.R. China.
  • Zhang J; School of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan 410128, P.R. China.
  • Zhang J; College of Chemistry, Food Laboratory of Zhongyuan, Flavour Science Research Center of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
  • Fang J; School of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan 410128, P.R. China.
Research (Wash D C) ; 7: 0464, 2024.
Article en En | MEDLINE | ID: mdl-39253100
ABSTRACT
Rational regulation of reactive oxygen species (ROS) plays a vital importance in maintaining homeostasis of living biological systems. For ROS-related pathologies, chemotherapy technology derived from metal nanomaterials currently occupies a pivotal position. However, they suffer from inherent issues such as complicated synthesis, batch-to-batch variability, high cost, and potential biological toxicity caused by metal elements. Here, we reported for the first time that dual-action 3,5-dihydroxy-1-ketonaphthalene-structured small-molecule enzyme imitator (DHKNase) exhibited 2-edged ROS regulation, catering to the execution of physiology-beneficial ROS destiny among diverse pathologies in living systems. Based on this, DHKNase is validated to enable remarkable therapeutic effects in 2 classic disease models, including the pathogen-infected wound-healing model and the dextran sulfate sodium (DSS)-caused inflammatory bowel disease (IBD). This work provides a guiding landmark for developing novel natural small-molecule enzyme imitator and significantly expands their application potential in the biomedical field.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Research (Wash D C) Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Research (Wash D C) Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos