Abdominal obesity is associated with increased worsening renal function risk in patients with heart failure with preserved ejection fraction.
BMC Cardiovasc Disord
; 24(1): 477, 2024 Sep 09.
Article
en En
| MEDLINE
| ID: mdl-39251903
ABSTRACT
BACKGROUND:
Worsening renal function (WRF) is a frequent comorbidity of heart failure with preserved ejection fraction (HFpEF). However, its relationship with abdominal obesity in terms of HFpEF remains unclear. This study aimed to evaluate the value of waist circumference (WC) and body mass index (BMI) in predicting WRF and examine the correlation between abdominal obesity and the risk of WRF in the HFpEF population.METHODS:
Data were obtained from the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist trial. Abdominal obesity was defined as WC ≥ 102 cm for men and ≥ 88 cm for women. WRF was defined as doubling of serum creatinine concentration from baseline. Restricted cubic splines and receiver operating characteristic curves were used to evaluate the value of WC and BMI in predicting WRF. Cumulative incidence curves and cox proportional-hazards models were used to compare patients with and without abdominal obesity.RESULTS:
We included 2,806 patients with HFpEF in our study (abdominal obesity, n 2,065). Although baseline creatinine concentrations did not differ, patients with abdominal obesity had higher concentrations during a median follow-up time of 40.9 months. Unlike BMI, WC exhibited a steady linear association with WRF and was a superior WRF predictor. Patients with abdominal obesity exhibited a higher risk of WRF after multivariable adjustment (hazard ratio 1.632; 95% confidence interval 1.015-2.621; P 0.043).CONCLUSIONS:
Abdominal obesity is associated with an increased risk of WRF in the HFpEF population. TRIAL REGISTRATION URL https//beta. CLINICALTRIALS gov . Unique identifier NCT00094302.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Volumen Sistólico
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Índice de Masa Corporal
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Antagonistas de Receptores de Mineralocorticoides
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Circunferencia de la Cintura
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Obesidad Abdominal
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Insuficiencia Cardíaca
/
Riñón
Límite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
BMC Cardiovasc Disord
Asunto de la revista:
ANGIOLOGIA
/
CARDIOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Reino Unido