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Demonstration of in-vivo simultaneous 3D imaging with 18F-FDG and Na131I using Compton-PET system.
Kim, Donghwan; Yan, Linlin; Shimazoe, Kenji; Takahashi, Hiroyuki; Ogane, Kenichiro; Yoshino, Masao; Kamada, Kei; Uenomachi, Mizuki.
Afiliación
  • Kim D; Department of Nuclear Engineering and Management, The University of Tokyo, 7-3-1 Hongo, Bunkyo City, Tokyo, Japan. kdhkdh0711@gmail.com.
  • Yan L; Department of Bioengineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo City, Tokyo, Japan.
  • Shimazoe K; Department of Nuclear Engineering and Management, The University of Tokyo, 7-3-1 Hongo, Bunkyo City, Tokyo, Japan.
  • Takahashi H; Department of Nuclear Engineering and Management, The University of Tokyo, 7-3-1 Hongo, Bunkyo City, Tokyo, Japan.
  • Ogane K; Department of Bioengineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo City, Tokyo, Japan.
  • Yoshino M; Department of Nuclear Medicine, International University of Health and Welfare, 1-4-3 Mita, Minato City, Tokyo, Japan.
  • Kamada K; Institute for Materials Research, Tohoku University, 6-6-10 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8579, Japan.
  • Uenomachi M; New Industry Creation Hatchery Center, Tohoku University, 6-6-10 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8579, Japan.
Sci Rep ; 14(1): 20946, 2024 09 09.
Article en En | MEDLINE | ID: mdl-39251751
ABSTRACT
Simultaneous imaging of the SPECT tracer 131I and PET tracer 18F is important in the diagnosis of high- and low-grade thyroid cancers because high-grade thyroid cancers have high 18F-FDG and low 131I uptake, while low-grade thyroid cancers have high 131I and low 18F-FDG uptake. In this study, Na131I and 18F-FDG were simultaneously imaged using the Compton-PET system, in vivo. The angular resolution and sensitivity of the Compton camera with 356 keV gamma ray measured using a 133Ba point source were 12.3° and 2 × 10-5, respectively. The spatial resolution and sensitivity of PET were measured with a 22Na point source. The transaxial and axial spatial resolutions of the PET at the center of the FOV were 1.15 mm and 2.04 mm, respectively. Its sensitivity was 1.2 × 10-4. In-vivo images of the 18F and 131I isotopes were simultaneously acquired from mice. These showed that 18F-FDG was active in the heart, brown fat, and brain, while Na131I was active in the thyroid, stomach, and bladder. Artifacts were found in the Compton camera images when the activity of 131I was much lower than that of 18F. This study demonstrates the potential of simultaneous clinical imaging of 18F and 131I.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fluorodesoxiglucosa F18 / Imagenología Tridimensional / Tomografía de Emisión de Positrones / Radioisótopos de Yodo Límite: Animals Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fluorodesoxiglucosa F18 / Imagenología Tridimensional / Tomografía de Emisión de Positrones / Radioisótopos de Yodo Límite: Animals Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido