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Perioperative outcomes of 105 cases of ABO-incompatible live donor kidney transplantation: a retrospective single-center observational study.
Shekhrajka, Praveenkumar; Mandal, Sony; Goyal, Vipin Kumar; Mittal, Saurabh; Khunteta, Nihit; Mishra, Akash.
Afiliación
  • Shekhrajka P; Department of Anaesthesia and Critical Care, Mahatma Gandhi Medical College and Hospital, Jaipur, India.
  • Mandal S; Department of Pathology, Mahatma Gandhi Medical College and Hospital, Jaipur, India.
  • Goyal VK; Department of Organ Transplant Anaesthesia and Critical Care, Mahatma Gandhi Medical College and Hospital, Jaipur, India.
  • Mittal S; Department of Organ Transplant Anaesthesia and Critical Care, Mahatma Gandhi Medical College and Hospital, Jaipur, India.
  • Khunteta N; Department of Anaesthesia and Critical Care, Mahatma Gandhi Medical College and Hospital, Jaipur, India.
  • Mishra A; Division of Biostatistics, Department of Community Medicine, Mahatma Gandhi Medical College and Hospital, Jaipur, India.
Clin Transplant Res ; 38(3): 197-202, 2024 Sep 30.
Article en En | MEDLINE | ID: mdl-39251569
ABSTRACT

Background:

ABO-incompatible (ABOi) kidney transplantation poses significant challenges in achieving successful outcomes. This study aimed to investigate the impact of various interventions and techniques on improving the success rates of ABOi kidney transplantation.

Methods:

We conducted a retrospective observational analysis of patients who underwent ABOi kidney transplantation from November 2012 to March 2023. The study included a total of 105 patients. We collected and analyzed data on patient demographics, preoperative assessments, surgical details, and postoperative outcomes.

Results:

The mean ages of the donors and recipients were 50.52±10.32 and 36.63±11.61 years, respectively. The majority of recipients were male (81.9%), while most donors were female (89.5%). The most common blood group among recipients was O (69.5%), and among donors, it was B (46.7%). The median durations of chronic kidney disease and dialysis were 12 months (interquartile range [IQR], 7-28 months) and 6 months (IQR, 2-12 months), respectively. Baseline antibody titers (anti-A and anti-B) ranged from 64.0 to 256.0, while on the day of surgery, they were ≤8. Perioperative complications included hypotension (10.5%), acute tubular necrosis (5.7%), delayed graft function (3.8%), and reexploration (3.8%) due to hematoma.

Conclusions:

ABOi kidney transplantation is a viable option for recipients lacking available donors with an ABO-compatible match. Perioperative concerns, including hypoalbuminemia, heightened risk of infections, coagulopathies, aseptic precautions, and immunological surveillance, must be carefully addressed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Transplant Res Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Corea del Sur
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Transplant Res Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Corea del Sur