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Short-term and Long-term Stability of the Autism Diagnostic Observation Schedule (ADOS-2) Calibrated Comparison Scores (CCS) and Classification Scores in Youth with Down Syndrome or Fragile X Syndrome with Intellectual Disability.
Thurman, Angela John; Nunnally, Amanda Dimachkie; Nguyen, Vivian; Berry-Kravis, Elizabeth; Sterling, Audra; Edgin, Jamie; Hamilton, Debra; Aschkenasy, Jeannie; Abbeduto, Leonard.
Afiliación
  • Thurman AJ; MIND Institute, University of California, Davis, 2825 50th Street, Room 2335, Sacramento, CA, 95817, USA. ajthurman@ucdavis.edu.
  • Nunnally AD; Department of Psychiatry and Behavioral Sciences, University of California Davis Medical Center, Sacramento, USA. ajthurman@ucdavis.edu.
  • Nguyen V; MIND Institute, University of California, Davis, 2825 50th Street, Room 2335, Sacramento, CA, 95817, USA.
  • Berry-Kravis E; Department of Psychiatry and Behavioral Sciences, University of California Davis Medical Center, Sacramento, USA.
  • Sterling A; MIND Institute, University of California, Davis, 2825 50th Street, Room 2335, Sacramento, CA, 95817, USA.
  • Edgin J; Department of Psychiatry and Behavioral Sciences, University of California Davis Medical Center, Sacramento, USA.
  • Hamilton D; Departments of Pediatrics, Neurological Sciences and Anatomy and Cell Biology, Rush University Medical Center, Chicago, USA.
  • Aschkenasy J; Waisman Center and Department of Communication Sciences and Disorders, University of Wisconsin-Madison, Madison, USA.
  • Abbeduto L; Department of Psychology, Virginia Tech, Blacksburg, USA.
J Autism Dev Disord ; 2024 Sep 09.
Article en En | MEDLINE | ID: mdl-39251531
ABSTRACT
Autism diagnosis in individuals with fragile X syndrome (FXS) or Down syndrome (DS) with co-occurring intellectual disability is complex since clinicians often must consider other co-occurring behavioral features. Understanding how best to assess the features of autism in individuals with these conditions is crucial. In this study, we consider the short-term and long-term psychometric consistency of the Autism Diagnostic Observation Schedule-2 (ADOS-2) calibrated comparison scores (CCSs) and ASD classifications in individuals with FXS or DS. 76 individuals with DS (39 males; Mage = 15.27) and 90 individuals with FXS (71 males; Mage = 14.52 years) completed an assessment battery (ADOS-2, abbreviated IQ assessment and semi-structured language sample) at three timepoints (initial visit, short-term stability visit, long-term stability visit). All CCSs were found to have short-and long-term consistency for both groups, with lowest reliability scores for the repetitive behaviors (RRB) CCSs. Decreased reliability of RRB CCSs was found in the DS group than the FXS group. Variable short- and long-term ASD classifications were observed in both groups, with significantly higher variability in the DS group. Across groups, participants with variable classifications had lower ADOS-2 CCSs and higher language scores than those with stable ASD classifications. In the FXS group, those with variable classifications earned higher cognitive scores than did participants with stable ASD classifications. These findings highlight the high incidence of autism symptomatology in individuals with DS or FXS and co-occurring intellectual disability, while elucidating the short- and long-term variability of symptom expression in the context of structured observational tasks such as the ADOS-2.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Autism Dev Disord Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Autism Dev Disord Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos