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A plant-based diet is feasible in patients with Crohn's disease.
Arvidsson, Line Birch; Lærke, Helle Nygaard; Lauridsen, Charlotte; Mikkelsen, Sabina; Rasmussen, Henrik Højgaard; Cetin, Zeynep; Østergaard, Stine Karstenskov; Holst, Mette.
Afiliación
  • Arvidsson LB; Department of Gastroenterology, Center for Nutrition and Intestinal Failure, Aalborg University Hospital, Sdr. Skovvej 5, 9000 Aalborg, Denmark; Department of Clinical Sciences, Aalborg University, Denmark.
  • Lærke HN; Aarhus University, Department of Animal and Veterinary Sciences, Blichers Allé 20, 8830 Tjele, Denmark.
  • Lauridsen C; Department of Clinical Sciences, Aalborg University, Denmark; Aarhus University, Department of Animal and Veterinary Sciences, Blichers Allé 20, 8830 Tjele, Denmark.
  • Mikkelsen S; Department of Gastroenterology, Center for Nutrition and Intestinal Failure, Aalborg University Hospital, Sdr. Skovvej 5, 9000 Aalborg, Denmark; Department of Clinical Sciences, Aalborg University, Denmark.
  • Rasmussen HH; Department of Gastroenterology, Center for Nutrition and Intestinal Failure, Aalborg University Hospital, Sdr. Skovvej 5, 9000 Aalborg, Denmark; Department of Clinical Sciences, Aalborg University, Denmark.
  • Cetin Z; Department of Gastroenterology, Center for Nutrition and Intestinal Failure, Aalborg University Hospital, Sdr. Skovvej 5, 9000 Aalborg, Denmark; Department of Clinical Sciences, Aalborg University, Denmark.
  • Østergaard SK; Department of Chemistry and Bioscience, Aalborg University, Aalborg, Denmark.
  • Holst M; Department of Gastroenterology, Center for Nutrition and Intestinal Failure, Aalborg University Hospital, Sdr. Skovvej 5, 9000 Aalborg, Denmark; Department of Clinical Sciences, Aalborg University, Denmark. Electronic address: mette.holst@rn.dk.
Clin Nutr ESPEN ; 64: 28-36, 2024 Sep 07.
Article en En | MEDLINE | ID: mdl-39251088
ABSTRACT

BACKGROUND:

Incorporating plant-based diets as a supplement to medical treatment may have a beneficial impact on patients with Crohn's disease, however, research with intervention studies is required.

OBJECTIVE:

To investigate the feasibility of a plant-based diet intervention. Secondly, the purpose was to investigate whether such diet may reduce disease activity and enhance quality of life. MATERIALS AND

METHODS:

This study was designed as a single arm feasibility study. Outpatients with Crohn's disease in biological therapy were guided over twelve weeks towards a dietary lifestyle change. OUTCOME

MEASURES:

Feasibility concerning recruitment, retention rate and compliance. Secondary outcomes were measures of patient reported outcome questionnaires (PROMS). Paired t-tests were used to examine changes in CO2 emissions, anthropology, biomarkers, and patient-reported data. Δ-values were used to investigate difference between dietary intake and requirements. Linear regression analyses examined the association between biomarkers and PROMS.

RESULTS:

In total, 15 participants completed the intervention with easy recruitment and a retention rate at 87.6%. A clinically positive tendency was seen towards improved symptom scores for disease (HBI; p=0.028 and IBDQ; p=0.006) but not for fatigue (IBD-F; p = 0.097), although none of these were statistically significant. Adverse effects were decreased protein intake (p=0.069) and slightly reduced muscle mass. It remains unclear to what extent the intervention contributed to the improved self-reported effects although perception of disease activity was improved.

CONCLUSION:

This study demonstrates that it is possible to retain patients following a plant-based diet. However, the dietary change required ongoing dietetic support with a focus on anti-inflammatory agents and the still unattainable protein requirements.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Nutr ESPEN Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Nutr ESPEN Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido