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Neonatal anesthesia with remimazolam Reduces the expression of synaptic proteins and increases depressive behavior in adult mice.
Tang, Zili; Sun, Siyi; Lin, Zhonglan; Wen, Yuxin; Li, Shuxin; Shen, Jiahong; Sun, Jianliang.
Afiliación
  • Tang Z; The Fourth Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, China.
  • Sun S; PROYA Cosmetics Co., Ltd, PROYA Building, No. 588 Xixi Road, Xihu District, Hangzhou 310023, China.
  • Lin Z; The Fourth Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, China.
  • Wen Y; Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, No. 261, Huansha Road, Shangcheng district, Hangzhou 310006, China.
  • Li S; The Fourth Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, China; Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, No. 261, Huansha Road, Shangcheng district, Hangzhou 310006, China.
  • Shen J; Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, No. 261, Huansha Road, Shangcheng district, Hangzhou 310006, China.
  • Sun J; The Fourth Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, China; Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, No. 261, Huansha Road, Shangcheng district, Hangzhou 310006, China. Electronic address: sjl6805@zju.edu.cn.
Neurosci Lett ; 842: 137971, 2024 Nov 01.
Article en En | MEDLINE | ID: mdl-39251083
ABSTRACT
The demand for pediatric anesthesia has risen in decades, raising concerns about the neurotoxic potential of anesthetics like remimazolam, which may impact neurodevelopment and later cognitive function. This study utilized a neonatal mouse model to assess remimazolam's neurodevelopmental effects. Results indicate that remimazolam-exposed mice displayed cognitive impairment and depressive behaviors in adulthood. Acute reductions in synaptic protein expression post-anesthesia were observed, along with long-term decreases in hippocampal choline acetyltransferase levels, reduced dendritic spine density in the CA1 region, and microglial proliferation. Collectively, these findings suggest that remimazolam can induce neurotoxicity and neuroinflammation, leading to synaptic dysfunction and associated cognitive and behavioral deficits.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzodiazepinas / Depresión / Animales Recién Nacidos Límite: Animals Idioma: En Revista: Neurosci Lett Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzodiazepinas / Depresión / Animales Recién Nacidos Límite: Animals Idioma: En Revista: Neurosci Lett Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Irlanda