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Rapidly molded sodium alginate/soy protein adhesive hydrogel with 808-nm laser inhibition of infected wounds.
He, Lei; Li, Genyuan; Wang, Heyan; Li, Yuanchao; Ma, Yuanyuan; Cui, Juqing; Shen, Jian; Zhang, Jun; Liu, Yongze; Ma, Xiaofeng.
Afiliación
  • He L; School of Chemistry and Materials Science, National and Local Joint Engineering Research Center of Biomedical Functional Materials, Nanjing Normal University (NNU), Nanjing 210023, China; College of Materials Science and Engineering, Nanjing Forestry University (NFU), Nanjing 210037, China.
  • Li G; School of Chemistry and Materials Science, National and Local Joint Engineering Research Center of Biomedical Functional Materials, Nanjing Normal University (NNU), Nanjing 210023, China.
  • Wang H; Department of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Medical Key Discipline (Laboratory), Research Institute of Otolaryngology, Nanjing 210008, China.
  • Li Y; Department of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Medical Key Discipline (Laboratory), Research Institute of Otolaryngology, Nanjing 210008, China.
  • Ma Y; College of Materials Science and Engineering, Nanjing Forestry University (NFU), Nanjing 210037, China.
  • Cui J; College of Materials Science and Engineering, Nanjing Forestry University (NFU), Nanjing 210037, China.
  • Shen J; School of Chemistry and Materials Science, National and Local Joint Engineering Research Center of Biomedical Functional Materials, Nanjing Normal University (NNU), Nanjing 210023, China.
  • Zhang J; School of Chemistry and Materials Science, National and Local Joint Engineering Research Center of Biomedical Functional Materials, Nanjing Normal University (NNU), Nanjing 210023, China. Electronic address: zhangjun3@njnu.edu.cn.
  • Liu Y; Department of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Medical Key Discipline (Laboratory), Research Institute of Otolaryngology, Nanjing 210008, China; Department of Otolaryngology Head and Neck Surgery, Nanjing Dr
  • Ma X; Department of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Medical Key Discipline (Laboratory), Research Institute of Otolaryngology, Nanjing 210008, China; Department of Otolaryngology Head and Neck Surgery, Nanjing Dr
Int J Biol Macromol ; 279(Pt 3): 135471, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39251004
ABSTRACT
Infected wounds produce pus and heal slowly. To address this issue, we developed a rapid-setting SP/SA@BP-C hydrogel by combining sodium alginate (SA) and soy protein (SP) with black phosphorus (BP) grafted with clarithromycin (Cla) and incorporating Ca2+ for chelation. This hydrogel dressing exhibits excellent photothermal (PT) and photodynamic (PD) bacteriostatic effects without biotoxicity, making it suitable for treating infected wounds. Characterization confirmed its successful fabrication, and the bacteriostatic effect demonstrated over 99 % efficacy through the synergistic effects of PT, PD, and Cla. Cellular studies indicated nontoxicity and a promoting effect on cell proliferation (121.6 %). In the mouse-infected wound model, the hydrogel led to complete healing in 12 days, with good recovery of the skin's superficial dermal layer and appendages. Consequently, SP/SA@BP-C is a natural hydrogel dressing with promising properties.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Proteínas de Soja / Hidrogeles / Alginatos Límite: Animals / Humans Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Proteínas de Soja / Hidrogeles / Alginatos Límite: Animals / Humans Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos