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Pearls & Oy-sters: Exquisite Response of Sleep-Related Hypermotor Epilepsy to a Nicotine Patch.
Nam, Spencer; Von Stein, Erica L; Meador, Kimford J; Levy, Rebecca J; Gallentine, William; Li, Yi.
Afiliación
  • Nam S; From the Department of Neurology and Neurological Sciences, Stanford University, CA.
  • Von Stein EL; From the Department of Neurology and Neurological Sciences, Stanford University, CA.
  • Meador KJ; From the Department of Neurology and Neurological Sciences, Stanford University, CA.
  • Levy RJ; From the Department of Neurology and Neurological Sciences, Stanford University, CA.
  • Gallentine W; From the Department of Neurology and Neurological Sciences, Stanford University, CA.
  • Li Y; From the Department of Neurology and Neurological Sciences, Stanford University, CA.
Neurology ; 103(7): e209790, 2024 Oct 08.
Article en En | MEDLINE | ID: mdl-39250747
ABSTRACT
Sleep-related hypermotor epilepsy (SHE), previously known as nocturnal frontal lobe epilepsy, is characterized by brief (<2 minutes) seizures with abrupt onset and offset and stereotyped focal or generalized hypermotor events occurring predominantly (but not exclusively) from sleep. Clinically, SHE can be challenging to distinguish from psychogenic nonepileptic events or sleep disorders. Up to 30% of SHE cases are drug-resistant, and SHE represents about 10% of drug-resistant surgical epilepsy cases. Although most cases have an unknown etiology, there is a subset of individuals with pathogenic variants in the subunits of n-acetylcholine receptors (nAChR). Furthermore, some individuals with nAChR variants are responsive to nicotine. We report a case of a 23-year-old man with SHE, but no pathogenic variant on testing, whose seizures were exquisitely responsive to removal and application of a nicotine patch. This suggests an alternative mechanism of nicotine in the suppression of seizures in individuals with SHE.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dispositivos para Dejar de Fumar Tabaco Límite: Adult / Humans / Male Idioma: En Revista: Neurology Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dispositivos para Dejar de Fumar Tabaco Límite: Adult / Humans / Male Idioma: En Revista: Neurology Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos