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Ultrasound-stimulated microbubbles to enhance radiotherapy: A scoping review.
McCorkell, Giulia; Piva, Terrence; Highgate, Declan; Nakayama, Masao; Geso, Moshi.
Afiliación
  • McCorkell G; RMIT University, Melbourne, Victoria, Australia.
  • Piva T; The University of Melbourne, Melbourne, Victoria, Australia.
  • Highgate D; RMIT University, Melbourne, Victoria, Australia.
  • Nakayama M; RMIT University, Melbourne, Victoria, Australia.
  • Geso M; RMIT University, Melbourne, Victoria, Australia.
J Med Imaging Radiat Oncol ; 68(6): 740-769, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39250692
ABSTRACT

INTRODUCTION:

Primarily used as ultrasound contrast agents, microbubbles have recently emerged as a versatile therapeutic vector that can be 'burst' to deliver payloads in the presence of suitably optimised ultrasound fields. Ultrasound-stimulated microbubbles (USMB) have recently demonstrated improvements in treatment outcomes across a variety of clinical applications. This scoping review investigates whether this potential translates into the context of radiation therapy by evaluating the application of this technology across all three phases of radiation action.

METHODS:

Primary research articles, excluding poster presentations and conference proceedings, were identified through systematic searches of the PubMed NCBI/Medline, Embase/OVID, Web of Science and CINAHL/EBSCOhost databases, with additional articles identified via manual Google Scholar searching. Articles were dual screened for inclusion using the Covidence systematic review platform and classified against all three phases of radiation action.

RESULTS:

Overall, 57 eligible publications from a total of 1389 identified articles were included in the review, with studies dating back to 2012. Study heterogeneity prevented formal statistical analysis; however, most articles reported improved outcomes using USMB in the presence of radiation compared to that of radiation alone. These improvements appear to result from the use of USMB as either a biovascular disruptor causing tumour cell damage via indirect mechanisms, or as a localised treatment vector that directly increases tumour cell uptake of other therapeutic and physical agents designed to enhance radiation action.

CONCLUSIONS:

USMB demonstrate exciting potential to enhance the effects of radiation treatments due to their versatility and capacity to target all three phases of radiation action.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microburbujas / Neoplasias Límite: Humans Idioma: En Revista: J Med Imaging Radiat Oncol Asunto de la revista: DIAGNOSTICO POR IMAGEM / NEOPLASIAS / RADIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Australia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microburbujas / Neoplasias Límite: Humans Idioma: En Revista: J Med Imaging Radiat Oncol Asunto de la revista: DIAGNOSTICO POR IMAGEM / NEOPLASIAS / RADIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Australia