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Relationships Between Hepatic Steatosis and Frailty Differ by HIV Serostatus.
Debroy, Paula; Barrett, Benjamin W; Erlandson, Kristine M; Budoff, Matthew; Brown, Todd T; Price, Jennifer C; Post, Wendy S; Stosor, Valentina; Skavarca, Carling; D'Souza, Gypsyamber; Lake, Jordan E.
Afiliación
  • Debroy P; Division of Infectious Diseases, UTHealth Houston, Houston, TX.
  • Barrett BW; Department of Endocrinology, Johns Hopkins University, Baltimore, MD.
  • Erlandson KM; Division of Infectious Diseases, University of Colorado Anschutz Medical Center, Aurora, CO.
  • Budoff M; The Lundquist Institute, Torrence, CA.
  • Brown TT; Department of Endocrinology, Johns Hopkins University, Baltimore, MD.
  • Price JC; Division of Hepatology, University of California San Francisco, San Francisco, CA.
  • Post WS; Department of Endocrinology, Johns Hopkins University, Baltimore, MD.
  • Stosor V; Division of Infectious Diseases, Northwestern University, Evanston, IL; and.
  • Skavarca C; Department of Infectious Diseases and Microbiology University of Pittsburgh, Pittsburgh, PA.
  • D'Souza G; Department of Endocrinology, Johns Hopkins University, Baltimore, MD.
  • Lake JE; Division of Infectious Diseases, UTHealth Houston, Houston, TX.
J Acquir Immune Defic Syndr ; 97(2): 165-171, 2024 Oct 01.
Article en En | MEDLINE | ID: mdl-39250650
ABSTRACT

BACKGROUND:

Frailty is associated with obesity-related comorbidities, but the relationship with nonalcoholic fatty liver disease (NAFLD) in people with HIV has been incompletely described. Our objective was to assess the associations between NAFLD and frailty.

METHODS:

Cross-sectional and longitudinal analysis of men in the Multicenter AIDS Cohort Study. NAFLD was defined as a liver/spleen ratio <1.0 on abdominal computed tomography scans; frailty was defined by the frailty phenotype as having 3 of the following weakness, slowness, weight loss, exhaustion, and low physical activity.

RESULTS:

Men without (n = 200) and with HIV (n = 292) were included. NAFLD prevalence was 21% vs 16% and frailty 12% vs 17%, respectively. Among men with NAFLD, frailty was more prevalent in men without HIV (21% vs 11%). In multivariate analysis, NAFLD was significantly associated with frailty after controlling for significant variables. Men without HIV and NAFLD had 2.6 times higher probability [95% confidence interval (CI) 1.2- to 5.7] of frailty relative to men with neither HIV nor NAFLD. This association was not seen in men with HIV. The probability of frailty was higher among men without HIV with NAFLD (27% vs 10% in men without NAFLD) but lower among men with HIV with NAFLD (14% vs 19% in men without NAFLD). No significant relationships were found in longitudinal analyses.

CONCLUSIONS:

NAFLD was independently associated with frailty among men without HIV but not men with HIV, despite increased prevalence of frailty among men with HIV. The mechanisms of the muscle-liver-adipose tissue axis underlying NAFLD might differ by HIV serostatus.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Enfermedad del Hígado Graso no Alcohólico / Fragilidad Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: J Acquir Immune Defic Syndr Asunto de la revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Enfermedad del Hígado Graso no Alcohólico / Fragilidad Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: J Acquir Immune Defic Syndr Asunto de la revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos