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Frequent Cocaine Use is Associated With Larger HIV Latent Reservoir Size.
Aouizerat, Bradley E; Garcia, Josephine N; Domingues, Carlos V; Xu, Ke; Quach, Bryan C; Page, Grier P; Konkle-Parker, Deborah; Bolivar, Hector H; Lahiri, Cecile D; Golub, Elizabeth T; Cohen, Mardge H; Kassaye, Seble G; DeHovitz, Jack; Kuniholm, Mark H; Archin, Nancie M; Tien, Phyllis C; Hancock, Dana B; Johnson, Eric Otto.
Afiliación
  • Aouizerat BE; Department of Oral and Maxillofacial Surgery, New York University.
  • Garcia JN; Translational Research Center, New York University.
  • Domingues CV; Department of Oral and Maxillofacial Surgery, New York University.
  • Xu K; Translational Research Center, New York University.
  • Quach BC; Department of Oral and Maxillofacial Surgery, New York University.
  • Page GP; Translational Research Center, New York University.
  • Konkle-Parker D; Department of Psychiatry, School of Medicine, Yale University.
  • Bolivar HH; VA Connecticut Health Care.
  • Lahiri CD; Genomics and Translational Research Center, Analytics Practice Area, RTI International.
  • Golub ET; Genomics and Translational Research Center, Analytics Practice Area, RTI International.
  • Cohen MH; Fellow Program, RTI International.
  • Kassaye SG; Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, MS.
  • DeHovitz J; Division of Infectious Disease, University of Miami-ACRU, Miami, FL.
  • Kuniholm MH; Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA.
  • Archin NM; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.
  • Tien PC; Department of Medicine, Stroger Hospital, Cook County Health System, Chicago, IL.
  • Hancock DB; Department of Medicine, Division of Infectious Diseases, Georgetown University, Washington, DC.
  • Johnson EO; Department of Medicine, Division of Infectious Diseases, Downstate Health Sciences University, Brooklyn, NY.
J Acquir Immune Defic Syndr ; 97(2): 156-164, 2024 Oct 01.
Article en En | MEDLINE | ID: mdl-39250649
ABSTRACT

BACKGROUND:

Cocaine-one of the most frequently abused illicit drugs among persons living with HIV [people living with HIV (PLWH)]-slows the decline of viral production after antiretroviral therapy and is associated with higher HIV viral load, more rapid HIV progression, and increased mortality.

SETTING:

We examined the impact of cocaine use on the CD4+ T-cell HIV latent reservoir (HLR) in virally suppressed PLWH participating in a national, longitudinal cohort study of the natural and treated history of HIV in the United States.

METHODS:

CD4+ T-cell genomic DNA from 434 women of diverse ancestry (ie, 75% Black, 14% Hispanic, 12% White) who self-reported cocaine use (ie, 160 cocaine users, 59 prior users, 215 non-users) was analyzed using the Intact Proviral HIV DNA Assay, measuring intact provirus per 106 CD4+ T cells.

FINDINGS:

HIV latent reservoir size differed by cocaine use (ie, median [interquartile range] 72 [14-193] for never users, 165 [63-387] for prior users, 184 [28-502] for current users), which was statistically significantly larger in both prior (P = 0.023) and current (P = 0.001) cocaine users compared with never users.

CONCLUSIONS:

Cocaine use may contribute to a larger replication competent HLR in CD4+ T cells among virologically suppressed women living with HIV. Our findings are important because women are underrepresented in HIV reservoir studies and in studies of the impact of cocaine use on outcomes among PLWH.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T CD4-Positivos / Infecciones por VIH / Latencia del Virus / Carga Viral / Trastornos Relacionados con Cocaína Límite: Adult / Female / Humans / Middle aged País/Región como asunto: America do norte Idioma: En Revista: J Acquir Immune Defic Syndr Asunto de la revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T CD4-Positivos / Infecciones por VIH / Latencia del Virus / Carga Viral / Trastornos Relacionados con Cocaína Límite: Adult / Female / Humans / Middle aged País/Región como asunto: America do norte Idioma: En Revista: J Acquir Immune Defic Syndr Asunto de la revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos