Bis(imidazolidine)-Derived NCN Nickel-Pincer-Catalyzed Asymmetric Reactions.
Org Lett
; 2024 Sep 09.
Article
en En
| MEDLINE
| ID: mdl-39250615
ABSTRACT
A bis(imidazolidine)-derived NCN nickel-pincer complex (tBu-PhBidine-Ni-OTf NCN-Ni-OTf) was synthesized by the oxidative addition of imidazolidine-containing aryl triflate to Ni(cod)2 in MeCN. NCN-Ni-OTf exhibited asymmetric induction in three reactions. In the Friedel-Crafts reaction of indoles with N-Boc imines, 3-indolylmethanamine products were obtained in 79% yield with 99% ee. In a conjugate addition reaction of malononitrile to nitroalkenes, products were obtained in 95% yield with 75% ee. In iodolactonization, the pincer-Ni complex showed catalytic activity superior to that of tBu-PhBidine-Pd-OTf.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Estados Unidos