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Investigation and quantification of composition variability in urinary stone analysis.
Le, Binh Duy; Oh, Kyung-Jin; Le, Anh Tuan; Hoang, Long; Park, Ilwoo.
Afiliación
  • Le BD; Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju, Korea.
  • Oh KJ; Department of Urology, Saint Paul Hospital, Hanoi, Vietnam.
  • Le AT; Department of Urology, Chonnam National University Medical School and Hospital, Gwangju, Korea.
  • Hoang L; Department of Urology, Hanoi Medical University Hospital, Hanoi, Vietnam.
  • Park I; Department of Surgery, Hanoi Medical University, Hanoi, Vietnam.
Investig Clin Urol ; 65(5): 511-517, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39249925
ABSTRACT

PURPOSE:

To investigate the variability in urinary stone composition analysis due to sampling and suggest potential solutions. MATERIALS AND

METHODS:

We collected 1,135 stone fragments from 149 instances that had undergone a stone removal at Hanoi Medical University Hospital from January 2022 to August 2022. Each fragment was ground into fine powder and divided into separate specimens if the amount was abundant. For composition analyzing every specimen, Fourier transform infrared spectroscopy was performed. The composition of a given fragment was the average of its belonging specimens. The variability in composition was assessed on the fragment level (i.e., between fragments of an instance). We defined an instance as "significantly variable" if the maximum difference in any composition across its belonging fragments was equal to or greater than a given threshold.

RESULTS:

On average, there were 7.6±3.3 stone fragments per instance and 2.3±0.5 specimens per fragment. We found that the variability could be substantial on the fragment level. Eighty-nine (69.5%) and 70 (54.7%) out of 128 multiple-component instances were significantly variable if the threshold was set at 20% and 30%, respectively. The variability of an instance on the fragment level was correlated with the size of fragment and the number of components.

CONCLUSIONS:

Our study demonstrated the significant variability in urinary stone composition and showed that it correlated with the size and the impurity of samples. Mapping denotation while sampling and analyzing as well as reporting the composition of individual fragments could be valuable to reduce potential variability.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cálculos Urinarios Límite: Humans Idioma: En Revista: Investig Clin Urol Año: 2024 Tipo del documento: Article Pais de publicación:
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cálculos Urinarios Límite: Humans Idioma: En Revista: Investig Clin Urol Año: 2024 Tipo del documento: Article Pais de publicación: