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Smaller Left Ventricular Size But Preserved Function in Adolescents and Adults Born Preterm.
Barton, Gregory P; Chandra, Alvin; Sanchez-Solano, Nataly; Berry, Jarett D; Goss, Kara N.
Afiliación
  • Barton GP; Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX.
  • Chandra A; Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX.
  • Sanchez-Solano N; Department of Pediatrics University of Texas Southwestern Medical Center Dallas TX.
  • Berry JD; Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX.
  • Goss KN; Department of Internal Medicine University of Texas Health Tyler Tyler TX.
J Am Heart Assoc ; 13(18): e035529, 2024 Sep 17.
Article en En | MEDLINE | ID: mdl-39248261
ABSTRACT

BACKGROUND:

Prematurely born adults have increased risk for cardiovascular disease. There are limited cardiac data on US-born preterm individuals. We aimed to determine whether adolescents and adults born prematurely have altered left ventricular (LV) structure and function, and to interrogate diastolic function using isometric handgrip exercise. METHODS AND

RESULTS:

Adolescents and adults born moderately to extremely preterm (≤32 weeks gestation or <1500 g birth weight) were recruited from the Parkland Health Neonatal Intensive Care Unit Registry. Full-term participants were recruited from the local area. Study procedures included anthropometrics and vitals, handgrip testing, and echocardiography performed at rest and during isometric handgrip exercise. Data were reported as mean±SD. The study enrolled 107 preterm and 48 term participants. Preterm participants (gestational age 29.5±2.5 weeks) were shorter with higher body mass index (P<0.001) compared with term participants. Preterm participants exhibited smaller LV end-diastolic volume index (50.8±10.1 versus 56.9±10.0 mL/m2, P<0.001), LV stroke volume index (29.6±6.0 versus 34.1±6.5 mL/m2, P<0.001), and LV mass index (67.2±13.1 versus 73.3±14.2 g/m2, P=0.002) compared with term individuals. Preterm participants also had subclinical reductions in LV peak systolic tissue velocity and peak early diastolic tissue velocity lateral at rest. Isometric handgrip exercise promoted a reduction in diastolic function and an increase in hemodynamic measures, but changes during isometric handgrip exercise were similar between groups.

CONCLUSIONS:

Adolescents and adults born preterm exhibit overall normal cardiac function despite smaller cardiac volumes and mass compared with individuals born full term. Effects are most pronounced at the lowest gestational ages.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Función Ventricular Izquierda / Edad Gestacional / Fuerza de la Mano / Ventrículos Cardíacos Límite: Adolescent / Adult / Female / Humans / Male / Newborn Idioma: En Revista: J Am Heart Assoc Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Función Ventricular Izquierda / Edad Gestacional / Fuerza de la Mano / Ventrículos Cardíacos Límite: Adolescent / Adult / Female / Humans / Male / Newborn Idioma: En Revista: J Am Heart Assoc Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido