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Plasma renin activity as a marker for predicting the antihypertensive effect of switching to sacubitril/valsartan in treated hypertensive patients: Usefulness in daily clinical practice.
Horio, Takeshi; Iwashima, Yoshio; Yoshiyama, Minoru; Fukuda, Daiju; Rai, Tatemitsu; Fujimoto, Kohei.
Afiliación
  • Horio T; Department of Cardiovascular Medicine, Ishikiriseiki Hospital, Higashiosaka, Japan.
  • Iwashima Y; Department of Internal Medicine, Kansai Medical University Kori Hospital, Neyagawa, Japan.
  • Yoshiyama M; Department of Nephrology and Hypertension, Dokkyo Medical University, Mibu, Japan.
  • Fukuda D; Department of Internal Medicine, Daito Central Hospital, Daito, Japan.
  • Rai T; Department of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
  • Fujimoto K; Department of Nephrology and Hypertension, Dokkyo Medical University, Mibu, Japan.
J Clin Hypertens (Greenwich) ; 26(10): 1196-1200, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39248193
ABSTRACT
The authors investigated the antihypertensive effect of sacubitril/valsartan (Sac/Val) when switching from other drugs and assessed whether brain natriuretic peptide (BNP) or plasma renin activity (PRA) before drug switching was a predictor of blood pressure lowering after switching to Sac/Val. In 92 patients with treated hypertension, clinic blood pressure, plasma BNP, and PRA were examined before and after switching to Sac/Val. Clinic systolic and diastolic blood pressures significantly decreased after drug switching to Sac/Val (p < .0001, respectively). The level before drug switching of BNP had no correlation with the change in systolic blood pressure (Δ-SBP) before and after switching to Sac/Val, but that of PRA was significantly correlated with Δ-SBP (r = .3807, p = .0002). A multiple regression analysis revealed that PRA before drug switching was an independent determinant of Δ-SBP. Our findings suggest that low PRA may become a useful marker to predict the antihypertensive effect of switching to Sac/Val in treated hypertensive patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tetrazoles / Compuestos de Bifenilo / Presión Sanguínea / Biomarcadores / Renina / Péptido Natriurético Encefálico / Combinación de Medicamentos / Antagonistas de Receptores de Angiotensina / Valsartán / Aminobutiratos Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Hypertens (Greenwich) Asunto de la revista: ANGIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tetrazoles / Compuestos de Bifenilo / Presión Sanguínea / Biomarcadores / Renina / Péptido Natriurético Encefálico / Combinación de Medicamentos / Antagonistas de Receptores de Angiotensina / Valsartán / Aminobutiratos Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Hypertens (Greenwich) Asunto de la revista: ANGIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos