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Association of remnant cholesterol with sarcopenia in Korean adults: a nationwide population-based study using data from the KNHANES.
Jang, Soo Yeon; Hwang, Soon-Young; Jang, Ahreum; Kim, Kyeong Jin; Yu, Ji Hee; Kim, Nam Hoon; Yoo, Hye Jin; Kim, Nan Hee; Baik, Sei Hyun; Choi, Kyung Mook.
Afiliación
  • Jang SY; Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
  • Hwang SY; Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea.
  • Jang A; Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
  • Kim KJ; Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
  • Yu JH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
  • Kim NH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
  • Yoo HJ; Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
  • Kim NH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
  • Baik SH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
  • Choi KM; Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
Front Endocrinol (Lausanne) ; 15: 1391733, 2024.
Article en En | MEDLINE | ID: mdl-39247920
ABSTRACT

Background:

Mounting evidence indicates the importance of the interplay between skeletal muscles and lipid metabolism. Remnant cholesterol (remnant-C) is considered one of the principal residual risk factors for cardiovascular disease and metabolic disorders; however, there are limited studies on the impact of remnant-C on sarcopenia.

Methods:

Data from the Korea National Health and Nutrition Examination Surveys (KNHANES) between 2008 and 2011 were used in this nationwide population-based study. In total, 17,408 participants were enrolled in this study. The subjects were categorized into four groups according to the quartile of remnant-C values. We conducted multivariable logistic regression analysis to evaluate the association between remnant-C and muscle mass measured using dual-energy X-ray absorptiometry.

Results:

A total of 1,791 participants (10.3%) presented low muscle mass, and there was a sequential increase in the percentage of low muscle mass across remnant-C quartiles (Q1, 5.2%; Q2, 8.7%; Q3, 11.5%; Q4, 15.7%). In the full adjusted model, those in the highest remnant-C quartile group showed significantly increased odds ratio (OR) for low muscle mass compared with those in the lowest remnant-C group after adjusting for various confounding factors (OR = 1.33, 95% confidence interval (CI) = 1.06-1.68, P <0.05). A wide range of subgroups and sensitivity analyses showed consistent results, supporting the robustness of our findings.

Conclusions:

Increased remnant-C value was associated with a high risk of low muscle mass in the Korean population. Remnant-C may be a novel marker for the prediction and management of sarcopenia in aging societies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encuestas Nutricionales / Colesterol / Sarcopenia Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2024 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encuestas Nutricionales / Colesterol / Sarcopenia Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2024 Tipo del documento: Article Pais de publicación: Suiza