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The duct of von Ebner's glands is a source of Sox10 + taste bud progenitors and susceptible to pathogen infections.
Yu, Wenxin; Kastriti, Maria Eleni; Ishan, Mohamed; Choudhary, Saurav Kumar; Rashid, Md Mamunur; Kramer, Naomi; Do, Hy Gia Truong; Wang, Zhonghou; Xu, Ting; Schwabe, Robert F; Ye, Kaixiong; Adameyko, Igor; Liu, Hong-Xiang.
Afiliación
  • Yu W; Department of Animal and Dairy Science, Regenerative Bioscience Center, College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA, United States.
  • Kastriti ME; Department of Neuroimmunology, Medical University of Vienna, Vienna, Austria.
  • Ishan M; Department of Animal and Dairy Science, Regenerative Bioscience Center, College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA, United States.
  • Choudhary SK; Institute of Bioinformatics, University of Georgia, Athens, GA, United States.
  • Rashid MM; Department of Animal and Dairy Science, Regenerative Bioscience Center, College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA, United States.
  • Kramer N; Department of Animal and Dairy Science, Regenerative Bioscience Center, College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA, United States.
  • Do HGT; Department of Genetics, University of Georgia, Athens, GA, United States.
  • Wang Z; Department of Animal and Dairy Science, Regenerative Bioscience Center, College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA, United States.
  • Xu T; Department of Animal and Dairy Science, Regenerative Bioscience Center, College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA, United States.
  • Schwabe RF; Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, United States.
  • Ye K; Institute of Bioinformatics, University of Georgia, Athens, GA, United States.
  • Adameyko I; Department of Genetics, University of Georgia, Athens, GA, United States.
  • Liu HX; Department of Neuroimmunology, Medical University of Vienna, Vienna, Austria.
Front Cell Dev Biol ; 12: 1460669, 2024.
Article en En | MEDLINE | ID: mdl-39247625
ABSTRACT

Introduction:

We have recently demonstrated that Sox10-expressing (Sox10 +) cells give rise to mainly type-III neuronal taste bud cells that are responsible for sour and salt taste. The two tissue compartments containing Sox10 + cells in the surrounding of taste buds include the connective tissue core of taste papillae and von Ebner's glands (vEGs) that are connected to the trench of circumvallate and foliate papillae.

Methods:

In this study, we performed single cell RNA-sequencing of the epithelium of Sox10-Cre/tdT mouse circumvallate/vEG complex and used inducible Cre mouse models to map the cell lineages of vEGs and/or connective tissue (including stromal and Schwann cells).

Results:

Transcriptomic analysis indicated that Sox10 expression was enriched in the cell clusters of vEG ducts that contained abundant proliferating cells, while Sox10-Cre/tdT expression was enriched in type-III taste bud cells and vEG ductal cells. In vivo lineage mapping showed that the traced cells were distributed in circumvallate taste buds concurrently with those in the vEGs, but not in the connective tissue. Moreover, multiple genes encoding pathogen receptors were enriched in the vEG ducts hosting Sox10 + cells.

Discussion:

Our data supports that it is the vEGs, not connective tissue core, that serve as the niche of Sox10 + taste bud progenitors. If this is also true in humans, our data indicates that vEG duct is a source of Sox10 + taste bud progenitors and susceptible to pathogen infections.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cell Dev Biol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cell Dev Biol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza