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Dynamic remodeling of septin structures fine-tunes myogenic differentiation.
Ugorets, Vladimir; Mendez, Paul-Lennard; Zagrebin, Dmitrii; Russo, Giulia; Kerkhoff, Yannic; Kotsaris, Georgios; Jatzlau, Jerome; Stricker, Sigmar; Knaus, Petra.
Afiliación
  • Ugorets V; Freie Universität Berlin, Institute of Chemistry and Biochemistry, Signal Transduction Group, 14195 Berlin, Germany.
  • Mendez PL; Freie Universität Berlin, Institute of Chemistry and Biochemistry, Signal Transduction Group, 14195 Berlin, Germany.
  • Zagrebin D; Max Planck Institute for Molecular Genetics, IMPRS-Biology and Computation, 14195 Berlin, Germany.
  • Russo G; Freie Universität Berlin, Institute of Chemistry and Biochemistry, Signal Transduction Group, 14195 Berlin, Germany.
  • Kerkhoff Y; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
  • Kotsaris G; Freie Universität Berlin, Institute of Chemistry and Biochemistry, Bionanointerfaces Group, 14195 Berlin, Germany.
  • Jatzlau J; Berlin-Brandenburg School for Regenerative Therapies, Charité - Universitätsmedizin Berlin, 13353 Berlin, Germany.
  • Stricker S; Freie Universität Berlin, Institute of Chemistry and Biochemistry, Musculoskeletal Development and Regeneration Group, 14195 Berlin, Germany.
  • Knaus P; Freie Universität Berlin, Institute of Chemistry and Biochemistry, Signal Transduction Group, 14195 Berlin, Germany.
iScience ; 27(9): 110630, 2024 Sep 20.
Article en En | MEDLINE | ID: mdl-39246450
ABSTRACT
Controlled myogenic differentiation is integral to the development, maintenance and repair of skeletal muscle, necessitating precise regulation of myogenic progenitors and resident stem cells. The transformation of proliferative muscle progenitors into multinuclear syncytia involves intricate cellular processes driven by cytoskeletal reorganization. While actin and microtubles have been extensively studied, we illuminate the role of septins, an essential yet still often overlooked cytoskeletal component, in myoblast architecture. Notably, Septin9 emerges as a critical regulator of myoblast differentiation during the initial commitment phase. Knock-down of Septin9 in C2C12 cells and primary mouse myoblasts accelerates the transition from proliferation to committed progenitor transcriptional programs. Furthermore, we unveil significant reorganization and downregulation of Septin9 during myogenic differentiation. Collectively, we propose that filmamentous septin structures and their orchestrated reorganization in myoblasts are part of a temporal regulatory mechanism governing the differentiation of myogenic progenitors. This study sheds light on the dynamic interplay between cytoskeletal components underlying controlled myogenic differentiation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: IScience Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: IScience Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos