Your browser doesn't support javascript.
loading
Oxygen-bridged W-Pd atomic pairs enable H2O2 activation for sensitive immunoassays.
Chen, Chengjie; Yan, Dongbo; Jia, Xiangkun; Li, Ruimin; Hu, Lijun; Li, Xiaotong; Jiao, Lei; Zhu, Chengzhou; Zhai, Yanling; Lu, Xiaoquan.
Afiliación
  • Chen C; Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University Qingdao 266071 P. R. China zhaiyanling@qdu.edu.cn jiaolei@qdu.edu.cn.
  • Yan D; Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University Qingdao 266071 P. R. China zhaiyanling@qdu.edu.cn jiaolei@qdu.edu.cn.
  • Jia X; Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University Qingdao 266071 P. R. China zhaiyanling@qdu.edu.cn jiaolei@qdu.edu.cn.
  • Li R; Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University Qingdao 266071 P. R. China zhaiyanling@qdu.edu.cn jiaolei@qdu.edu.cn.
  • Hu L; Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University Qingdao 266071 P. R. China zhaiyanling@qdu.edu.cn jiaolei@qdu.edu.cn.
  • Li X; Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University Qingdao 266071 P. R. China zhaiyanling@qdu.edu.cn jiaolei@qdu.edu.cn.
  • Jiao L; Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University Qingdao 266071 P. R. China zhaiyanling@qdu.edu.cn jiaolei@qdu.edu.cn.
  • Zhu C; National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University Wuhan 430079 P. R. China.
  • Zhai Y; Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University Qingdao 266071 P. R. China zhaiyanling@qdu.edu.cn jiaolei@qdu.edu.cn.
  • Lu X; Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University Qingdao 266071 P. R. China zhaiyanling@qdu.edu.cn jiaolei@qdu.edu.cn.
Chem Sci ; 2024 Aug 26.
Article en En | MEDLINE | ID: mdl-39246350
ABSTRACT
Regulating the performance of peroxidase (POD)-like nanozymes is a prerequisite for achieving highly sensitive and accurate immunoassays. Inspired by natural enzyme catalysis, we design a highly active and selective nanozyme by loading atomically dispersed tungsten (W) sites on Pd metallene (W-O-Pdene) to construct an artificial three-dimensional (3D) catalytic center. The 3D asymmetric W-O-Pd atomic pairs can effectively stretch the O-O bonds in H2O2 and further promote the desorption of H2O to enhance POD-like activity. Moreover, the W-O-Pd sites with unique spatial structures demonstrate satisfactory specificity for H2O2 activation, effectively preventing the interference of dissolved oxygen. Accordingly, the highly active and specific W-O-Pdene nanozymes are utilized for sensitive and accurate prostate-specific antigen (PSA) immunoassay with a low detection limit of 1.92 pg mL-1, superior to commercial enzyme-linked immunosorbent assay.
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Sci Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Sci Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido