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Biofilm mediated integrin activation and directing acceleration of colorectal cancer.
Saravanan, Vaijayanthi; Gopalakrishnan, Vinoj; Mahendran, Maria Infant Majula Shifani; Vaithianathan, Rajan; Srinivasan, Sowmya; Boopathy, Vinoth; Krishnamurthy, SriKrishna.
Afiliación
  • Saravanan V; MGM Advanced Research Institute, Sri Balaji Vidhyapeeth (Deemed to be University), Pondicherry, Tamil Nadu, India.
  • Gopalakrishnan V; MGM Advanced Research Institute, Sri Balaji Vidhyapeeth (Deemed to be University), Pondicherry, Tamil Nadu, India.
  • Mahendran MIMS; MGM Advanced Research Institute, Sri Balaji Vidhyapeeth (Deemed to be University), Pondicherry, Tamil Nadu, India.
  • Vaithianathan R; Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidhyapeeth (Deemed to be University), Pondicherry, Tamil Nadu, India.
  • Srinivasan S; Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidhyapeeth (Deemed to be University), Pondicherry, Tamil Nadu, India.
  • Boopathy V; Vinoth Gastro Liver Clinic, Cuddalore, Tamil Nadu, India.
  • Krishnamurthy S; Krishna Hospital and Research Institute, Cuddalore, Tamil Nadu, India.
APMIS ; 2024 Sep 09.
Article en En | MEDLINE | ID: mdl-39246244
ABSTRACT
Bacterial biofilm plays a vital role in influencing several diseases, infections, metabolic pathways and communication channels. Biofilm influence over colorectal cancer (CRC) has been a booming area of research interest. The virulence factors of bacterial pathogen have a high tendency to induce metabolic pathway to accelerate CRC. The bacterial species biofilm may induce cancer through regulating the major signalling pathways responsible for cell proliferation, differentiation, survival and growth. Activation of cancer signals may get initiated from the chronic infections through bacterial biofilm species. Integrin mediates in the activation of major pathway promoting cancer. Integrin-mediated signals are expected to be greatly influenced by biofilm. Integrins are identified as an important dimer, whose dysfunction may alter the signalling cascade specially focusing on TGF-ß, PI3K/Akt/mToR, MAPK and Wnt pathway. Along with biofilm shield, the tumour gains greater resistance from radiation, chemotherapy and also from other antibiotics. The biofilm barrier is known to cause challenges for CRC patients undergoing treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: APMIS Asunto de la revista: ALERGIA E IMUNOLOGIA / MICROBIOLOGIA / PATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Dinamarca
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: APMIS Asunto de la revista: ALERGIA E IMUNOLOGIA / MICROBIOLOGIA / PATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Dinamarca