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A phase II study of weekly carboplatin and concurrent radiotherapy in older adults with locally advanced non-small cell lung cancer (LOGIK1902).
Harada, Taishi; Sasaki, Tomonari; Ishii, Hidenobu; Takemoto, Shinnosuke; Hisamatsu, Yasushi; Saito, Haruhiro; Yoneshima, Yasuto; Komiya, Kazutoshi; Kashiwabara, Kosuke; Naoki, Katsuhiko; Ogawa, Tomohiro; Takeoka, Hiroaki; Saruwatari, Koichi; Ito, Kensaku; Tsuchiya-Kawano, Yuko; Mizuno, Keiko; Shimose, Takayuki; Shioyama, Yoshiyuki; Okamoto, Isamu.
Afiliación
  • Harada T; Department of Respiratory Medicine, Japan Community Healthcare Organization Kyushu Hospital, Kitakyusyu, Japan.
  • Sasaki T; Department of Radiation Oncology, Iizuka Hospital, Iizuka, Japan.
  • Ishii H; Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.
  • Takemoto S; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
  • Hisamatsu Y; Department of Thoracic Oncology, Oita Prefectural Hospital, Oita, Japan.
  • Saito H; Department of Thoracic Oncology, Kanagawa Cancer Center, Yokohama, Japan.
  • Yoneshima Y; Department of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Komiya K; Department of Respiratory Medicine, National Hospital Organization Ureshino Medical Center, Ureshino, Japan.
  • Kashiwabara K; Department of Respiratory Medicine, Kumamoto Regional Medical Center, Kumamoto, Japan.
  • Naoki K; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
  • Ogawa T; Department of Respiratory Medicine, Saiseikai Fukuoka General Hospital, Fukuoka, Japan.
  • Takeoka H; Department of Respiratory Medicine, NHO Kyushu Medical Center, Fukuoka, Japan.
  • Saruwatari K; Department of Respiratory Medicine, Kumamoto University Hospital, Kumamoto, Japan.
  • Ito K; Department of Thoracic Oncology, NHO Kyushu Cancer Center, Fukuoka, Japan.
  • Tsuchiya-Kawano Y; Department of Respiratory Medicine, Kitakyushu Municipal Medical Center, Kitakyushu, Japan.
  • Mizuno K; Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
  • Shimose T; Department of Statistics and Data Center, Clinical Research Support Center Kyushu, Fukuoka, Japan.
  • Shioyama Y; Ion Beam Therapy Center, SAGA HIMAT Foundation, Tosu, Japan.
  • Okamoto I; Department of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Thorac Cancer ; 15(29): 2128-2135, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39245951
ABSTRACT

BACKGROUND:

Concurrent chemoradiotherapy is the standard therapy for locally advanced non-small cell lung cancer (NSCLC). However, there is little evidence supporting its use in older adults. Low-dose daily carboplatin combined with thoracic radiotherapy is considered a standard regimen for this population. To establish a simple and feasible carboplatin administration method, we conducted a study of weekly carboplatin and concurrent radiotherapy for older adults with locally advanced NSCLC.

METHODS:

This prospective, single-arm, multicenter, phase II clinical trial included patients aged ≥75 years with unresectable stage III NSCLC and Eastern Cooperative Oncology Group performance status 0-1. Patients received chemoradiotherapy (60 Gy/30 fractions plus concurrent weekly carboplatin at an area under curve of 2 mg mL-1 min-1). The primary endpoint was the overall response rate (ORR). Key secondary endpoints included progression-free survival (PFS), overall survival (OS), and safety.

RESULTS:

From July 2020 to June 2022, 37 patients were enrolled from 15 institutions, and 36 patients were evaluable for efficacy and safety. The ORR was 63.9% (95% confidence interval [CI] = 47.6-77.5). Median PFS was 14.6 months (95% CI = 9.1-18.1). Median OS was 25.5 months (95% CI = 17.4-not reached). Grade 4 leucopenia, neutropenia, and thrombocytopenia were observed in one patient (2.8%) each.

CONCLUSION:

Weekly carboplatin and concurrent radiation therapy was safe in older adults with locally advanced NSCLC, and promising activity was observed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carboplatino / Carcinoma de Pulmón de Células no Pequeñas / Quimioradioterapia / Neoplasias Pulmonares Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Thorac Cancer Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Singapur
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carboplatino / Carcinoma de Pulmón de Células no Pequeñas / Quimioradioterapia / Neoplasias Pulmonares Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Thorac Cancer Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Singapur