Genotypic and phenotypic characterisation of asymptomatic bacteriuria (ABU) isolates displaying bacterial interference against multi-drug resistant uropathogenic E. Coli.
Arch Microbiol
; 206(10): 394, 2024 Sep 09.
Article
en En
| MEDLINE
| ID: mdl-39245770
ABSTRACT
Escherichia coli can colonise the urogenital tract of individuals without causing symptoms of infection, in a condition referred to as asymptomatic bacteriuria (ABU). ABU isolates can protect the host against symptomatic urinary tract infections (UTIs) by bacterial interference against uropathogenic E. coli (UPEC). The aim of this study was to investigate the genotypic and phenotypic characteristics of five ABU isolates from midstream urine samples of adults. Comparative genomic and phenotypic analysis was conducted including an antibiotic resistance profile, pangenome analysis, and a putative virulence profile. Based on the genome analysis, the isolates consisted of one from phylogroup A, three from phylogroup B2, and one from phylogroup D. Two of the isolates, PUTS 58 and SK-106-1, were noted for their lack of antibiotic resistance and virulence genes compared to the prototypic ABU strain E. coli 83,972. This study provides insights into the genotypic and phenotypic profiles of uncharacterised ABU isolates, and how relevant fitness and virulence traits can impact their potential suitability for therapeutic bacterial interference.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fenotipo
/
Bacteriuria
/
Infecciones Urinarias
/
Farmacorresistencia Bacteriana Múltiple
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Infecciones por Escherichia coli
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Escherichia coli Uropatógena
/
Genotipo
/
Antibacterianos
Límite:
Adult
/
Humans
Idioma:
En
Revista:
Arch Microbiol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Irlanda
Pais de publicación:
Alemania