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Copper doped carbon dots modified bacterial cellulose with enhanced antibacterial and immune regulatory functions for accelerating wound healing.
Liu, Yingyu; Zhao, Yifan; Guo, Susu; Qin, Danlei; Yan, Jingyu; Cheng, Huaiyi; Zhou, Jian; Ren, Jianing; Sun, Lingxiang; Peng, Hongyi; Wu, Xiuping; Li, Bing.
Afiliación
  • Liu Y; Shanxi Medical University School and Hospital of Stomatology, Taiyuan 030001, Shanxi, China; Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan 030001, Shanxi, China.
  • Zhao Y; Shanxi Medical University School and Hospital of Stomatology, Taiyuan 030001, Shanxi, China; Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan 030001, Shanxi, China.
  • Guo S; Shanxi Medical University School and Hospital of Stomatology, Taiyuan 030001, Shanxi, China; Academy of Medical Sciences, Shanxi Medical University, Taiyuan 030001, Shanxi, China.
  • Qin D; Shanxi Medical University School and Hospital of Stomatology, Taiyuan 030001, Shanxi, China; Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan 030001, Shanxi, China.
  • Yan J; Shanxi Medical University School and Hospital of Stomatology, Taiyuan 030001, Shanxi, China; Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan 030001, Shanxi, China.
  • Cheng H; Shanxi Medical University School and Hospital of Stomatology, Taiyuan 030001, Shanxi, China; Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan 030001, Shanxi, China.
  • Zhou J; Salivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and Beijing Stomatological Hospital, Capital Medical University, Beijing, China.
  • Ren J; Shanxi Medical University School and Hospital of Stomatology, Taiyuan 030001, Shanxi, China; Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan 030001, Shanxi, China.
  • Sun L; Shanxi Medical University School and Hospital of Stomatology, Taiyuan 030001, Shanxi, China; Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan 030001, Shanxi, China.
  • Peng H; Shanxi Medical University School and Hospital of Stomatology, Taiyuan 030001, Shanxi, China; Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan 030001, Shanxi, China.
  • Wu X; Shanxi Medical University School and Hospital of Stomatology, Taiyuan 030001, Shanxi, China; Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan 030001, Shanxi, China. Electronic address: 77wxp@163.com.
  • Li B; Shanxi Medical University School and Hospital of Stomatology, Taiyuan 030001, Shanxi, China; Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan 030001, Shanxi, China. Electronic address: libing-1975@163.com.
Carbohydr Polym ; 346: 122656, 2024 Dec 15.
Article en En | MEDLINE | ID: mdl-39245512
ABSTRACT
The microenvironment of wound healing is susceptible to bacterial infection, chronic inflammation, oxidative stress, and inadequate angiogenesis, requiring the development of innovative wound dressings with antibacterial, anti-inflammatory, antioxidant, and angiogenic capabilities. This research crafted a new multifunctional bacterial cellulose composite membrane infused with copper-doped carbon dots (BC/Cu(II)-RCDs). Findings validated the successful loading of copper-doped carbon dots onto the BC membrane via hydrogen bonding interactions. Compared to the pure BC membrane, the BC/Cu(II)-RCDs composite membrane exhibited significantly enhanced hydrophilicity, tensile properties, and thermal stability. Diverse in vitro assays demonstrated excellent biocompatibility and antibacterial activity of BC/Cu(II)-RCDs composite membranes, alongside their ability to expedite the inflammatory phase and stimulate angiogenesis. In vivo trials corroborated the membrane's ability to foster epithelial regeneration, collagen deposition, and tissue regrowth in full-thickness skin wounds in rats while also curbing inflammation in infected full-thickness skin wounds. More importantly, the treatment of the BC/Cu(II)-RCDs composite membrane may result in the activation of VEGF and MAPK signaling proteins, which are key players in cell migration, angiogenesis, and skin tissue development. In essence, the developed BC/Cu(II)-RCDs composite membrane shows promise for treating infected wounds and serves as a viable alternative material for medicinal bandages.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Carbono / Celulosa / Cobre / Antibacterianos Límite: Animals / Humans / Male Idioma: En Revista: Carbohydr Polym Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Carbono / Celulosa / Cobre / Antibacterianos Límite: Animals / Humans / Male Idioma: En Revista: Carbohydr Polym Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido