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Low methyl-esterified ginseng homogalacturonan pectins promote longevity of Caenorhabditis elegans via impairing insulin/IGF-1 signalling.
Wang, Jiayi; Wang, Yuan; Xu, Xuejiao; Song, Chengcheng; Zhou, Yuwei; Xue, Dongxue; Feng, Zhangkai; Zhou, Yifa; Li, Xiaoxue.
Afiliación
  • Wang J; Engineering Research Center of Glycoconjugates of the Ministry of Education, The Key Laboratory of Molecular Epigenetics of the Ministry of Education, School of Life Science, Northeast Normal University, Changchun 130024, China; School of Chemistry and Life Science, Changchun University of Technolog
  • Wang Y; Engineering Research Center of Glycoconjugates of the Ministry of Education, The Key Laboratory of Molecular Epigenetics of the Ministry of Education, School of Life Science, Northeast Normal University, Changchun 130024, China.
  • Xu X; Engineering Research Center of Glycoconjugates of the Ministry of Education, The Key Laboratory of Molecular Epigenetics of the Ministry of Education, School of Life Science, Northeast Normal University, Changchun 130024, China.
  • Song C; Engineering Research Center of Glycoconjugates of the Ministry of Education, The Key Laboratory of Molecular Epigenetics of the Ministry of Education, School of Life Science, Northeast Normal University, Changchun 130024, China.
  • Zhou Y; Engineering Research Center of Glycoconjugates of the Ministry of Education, The Key Laboratory of Molecular Epigenetics of the Ministry of Education, School of Life Science, Northeast Normal University, Changchun 130024, China.
  • Xue D; Engineering Research Center of Glycoconjugates of the Ministry of Education, The Key Laboratory of Molecular Epigenetics of the Ministry of Education, School of Life Science, Northeast Normal University, Changchun 130024, China.
  • Feng Z; Engineering Research Center of Glycoconjugates of the Ministry of Education, The Key Laboratory of Molecular Epigenetics of the Ministry of Education, School of Life Science, Northeast Normal University, Changchun 130024, China.
  • Zhou Y; Engineering Research Center of Glycoconjugates of the Ministry of Education, The Key Laboratory of Molecular Epigenetics of the Ministry of Education, School of Life Science, Northeast Normal University, Changchun 130024, China.
  • Li X; Engineering Research Center of Glycoconjugates of the Ministry of Education, The Key Laboratory of Molecular Epigenetics of the Ministry of Education, School of Life Science, Northeast Normal University, Changchun 130024, China. Electronic address: lixx956@nenu.edu.cn.
Carbohydr Polym ; 346: 122600, 2024 Dec 15.
Article en En | MEDLINE | ID: mdl-39245488
ABSTRACT
Panax ginseng C. A. Meyer (ginseng) is a medicinal plant widely used for promoting longevity. Recently, homogalacturonan (HG) domain-rich pectins purified from some plants have been reported to have anti-aging-related activities, leading us to explore the longevity-promoting activity of the HG pectins from ginseng. In this study, we discovered that two of low methyl-esterified ginseng HG pectins (named as WGPA-2-HG and WGPA-3-HG), whose degree of methyl-esterification (DM) was 16 % and 8 % respectively, promoted longevity in Caenorhabditis elegans. Results showed that WGPA-2-HG/WGPA-3-HG impaired insulin/insulin-like growth factor 1 (IGF-1) signalling (IIS) pathway, thereby increasing the nuclear accumulation of transcription factors SKN-1/Nrf2 and DAF-16/FOXO and enhancing the expression of relevant anti-aging genes. BLI and ITC analysis showed that the insulin-receptor binding, the first step to activate IIS pathway, was impeded by the engagement of WGPA-2-HG/WGPA-3-HG with insulin. By chemical modifications, we found that high methyl-esterification of WGPA-2-HG/WGPA-3-HG was detrimental for their longevity-promoting activity. These findings provided novel insight into the precise molecular mechanism for the longevity-promoting effect of ginseng pectins, and suggested a potential to utilize the ginseng HG pectins with appropriate DM values as natural nutrients for increasing human longevity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor I del Crecimiento Similar a la Insulina / Transducción de Señal / Pectinas / Caenorhabditis elegans / Proteínas de Caenorhabditis elegans / Panax / Insulina / Longevidad Límite: Animals Idioma: En Revista: Carbohydr Polym Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor I del Crecimiento Similar a la Insulina / Transducción de Señal / Pectinas / Caenorhabditis elegans / Proteínas de Caenorhabditis elegans / Panax / Insulina / Longevidad Límite: Animals Idioma: En Revista: Carbohydr Polym Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido