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S100A12 inhibits Streptococcus pneumoniae and aids in wound healing of corneal epithelial cells both in vitro and in vivo.
Mishra, Priyasha; Ch, Sanjay; Ghosh, Abhijit; Kundu, Srijita; Agarwal, Riddhi; Bhogapurapu, Bharathi; Biswas, Swati; Roy, Sanhita.
Afiliación
  • Mishra P; Prof. Brien Holden Eye Research Centre, LV Prasad Eye Institute, Hyderabad, India; Dr. Chigurupati Nageswara Rao Ocular Pharmacology Research Centre, LV Prasad Eye Institute, Hyderabad, India; Manipal Academy of Higher Education, Manipal, India.
  • Ch S; Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Hyderabad, India.
  • Ghosh A; Prof. Brien Holden Eye Research Centre, LV Prasad Eye Institute, Hyderabad, India; Dr. Chigurupati Nageswara Rao Ocular Pharmacology Research Centre, LV Prasad Eye Institute, Hyderabad, India.
  • Kundu S; Prof. Brien Holden Eye Research Centre, LV Prasad Eye Institute, Hyderabad, India; Dr. Chigurupati Nageswara Rao Ocular Pharmacology Research Centre, LV Prasad Eye Institute, Hyderabad, India; Manipal Academy of Higher Education, Manipal, India.
  • Agarwal R; Prof. Brien Holden Eye Research Centre, LV Prasad Eye Institute, Hyderabad, India; Dr. Chigurupati Nageswara Rao Ocular Pharmacology Research Centre, LV Prasad Eye Institute, Hyderabad, India; Manipal Academy of Higher Education, Manipal, India.
  • Bhogapurapu B; Prof. Brien Holden Eye Research Centre, LV Prasad Eye Institute, Hyderabad, India.
  • Biswas S; Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Hyderabad, India.
  • Roy S; Prof. Brien Holden Eye Research Centre, LV Prasad Eye Institute, Hyderabad, India; Dr. Chigurupati Nageswara Rao Ocular Pharmacology Research Centre, LV Prasad Eye Institute, Hyderabad, India. Electronic address: sanhita@lvpei.org.
Microbes Infect ; : 105421, 2024 Sep 07.
Article en En | MEDLINE | ID: mdl-39245174
ABSTRACT
Streptococcus pneumoniae, a leading cause of corneal infections worldwide, are extremely aggressive despite antibiotic sensitivity and exhibit increased resistance towards antibiotics. Antimicrobial peptides are often considered as potent alternatives against antibiotic resistance and here we have investigated the possible roles of S100A12, a host defense peptide, in wound healing and S. pneumoniae infection. S100A12 significantly inhibited growth of S. pneumoniae by disruption of membrane integrity along with increased generation of reactive oxygen species. Additionally, S100A12 accelerated cell migration and wound closure in human corneal epithelial cells and in a murine corneal wound model by activation of EGFR and MAPK signaling pathways.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Microbes Infect Asunto de la revista: ALERGIA E IMUNOLOGIA / MICROBIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Microbes Infect Asunto de la revista: ALERGIA E IMUNOLOGIA / MICROBIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Francia