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Computed tomography-based measurements associated with rapid lung function decline in severe asthma.
Sim, Da Woon; Choi, Sanghun; Jeong, Jinyoung; Lee, Suh-Young; Nam, Young-Hee; Kim, Byung-Keun; Lee, Young-Soo; Shim, Ji-Su; Yang, Min-Suk; Kim, Min-Hye; Kim, So Ri; Koh, Young-Il; Kim, Sang-Heon; Park, Heung-Woo.
Afiliación
  • Sim DW; Department of Allergy, Asthma and Clinical Immunology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Choi S; School of Mechanical Engineering, Kyungpook National University, Daegu, Republic of Korea.
  • Jeong J; School of Mechanical Engineering, Kyungpook National University, Daegu, Republic of Korea.
  • Lee SY; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
  • Nam YH; Department of Internal Medicine, Dong-A University College of Medicine, Busan, Republic of Korea.
  • Kim BK; Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
  • Lee YS; Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Republic of Korea.
  • Shim JS; Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Republic of Korea.
  • Yang MS; Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea.
  • Kim MH; Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Republic of Korea.
  • Kim SR; Division of Respiratory Medicine and Allergy, Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju, Republic of Korea.
  • Koh YI; Department of Allergy, Asthma and Clinical Immunology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Kim SH; Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea.
  • Park HW; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: guinea71@snu.ac.kr.
Ann Allergy Asthma Immunol ; 2024 Sep 05.
Article en En | MEDLINE | ID: mdl-39243811
ABSTRACT

BACKGROUND:

Severe asthma patients are susceptible to lung function decline (LFD), but biomarkers that reliably predict an accelerated LFD have not been fully recognized.

OBJECTIVE:

In this study, we explored the computed tomography (CT) imaging features within pre-defined LFD groups to identify variables associated with previous LFD occurrences in severe asthma patients.

METHODS:

We obtained inspiratory and expiratory CT image of 102 severe asthma patients and derived two airway structural parameters (wall thickness [WT] and hydraulic diameter [Dh]) and two parenchymal variables (functional small airway disease [fSAD] and emphysema [Emph]). We retrospectively calculated the annual changes in forced expiratory volume in 1 second and grouped participants by their values determined. The four-imaging metrics, along with levels of several biomarkers were compared among LFD groups.

RESULTS:

Severe asthma patients with enhanced LFD exhibited significantly lower WT and smaller Dh compared to those with minimal change or slight decline in lung function, after an adjustment of smoking status. Conversely, CT-based percentages of Emph and fSAD did not significantly differ according to LFD. Furthermore, fractional exhaled nitric oxide (FeNO) level and the blood matrix metalloproteinase-9/TIMP metallopeptidase inhibitor 1 ratio were significantly higher in severe asthma patients with enhanced LFD compared to those in the others.

CONCLUSION:

Lower WT on CT scans with increased FeNO that may represent increased airway inflammation significantly correlated with enhanced LFD in severe asthma patients. Consequently, active management plans may help to attenuate LFD for severe asthma patients with lower WT and high FeNO.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ann Allergy Asthma Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ann Allergy Asthma Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos