Your browser doesn't support javascript.
loading
Invasiveness modulation of glioma cells by copper complex-loaded nanoarchitectures.
Zamborlin, Agata; Pagliari, Francesca; Ermini, Maria Laura; Frusca, Valentina; García-Calderón, Daniel; Tirinato, Luca; Volante, Stefania; Bresciani, Giulio; Marchetti, Fabio; Seco, Joao; Voliani, Valerio.
Afiliación
  • Zamborlin A; Center for Nanotechnology Innovation@ NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro, 12, Pisa 56127, Italy; NEST-Scuola Normale Superiore, Piazza San Silvestro, 12, Pisa 56127, Italy.
  • Pagliari F; Division of BioMedical Physics in Radiation Oncology, German Cancer Research Center, Heidelberg 69120, Germany.
  • Ermini ML; Center for Nanotechnology Innovation@ NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro, 12, Pisa 56127, Italy.
  • Frusca V; Center for Nanotechnology Innovation@ NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro, 12, Pisa 56127, Italy; Scuola Superiore Sant'Anna, Piazza Martiri della Libertà, 33, Pisa 56127, Italy.
  • García-Calderón D; Division of BioMedical Physics in Radiation Oncology, German Cancer Research Center, Heidelberg 69120, Germany; Department of Physics and Astronomy, Heidelberg University, Im Neuenheimer Feld 227, Heidelberg 69120, Germany.
  • Tirinato L; Division of BioMedical Physics in Radiation Oncology, German Cancer Research Center, Heidelberg 69120, Germany; Department of Medical and Surgical Science, University Magna Graecia, Catanzaro 88100, Italy.
  • Volante S; Department of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, Pisa 56124, Italy.
  • Bresciani G; Department of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, Pisa 56124, Italy.
  • Marchetti F; Department of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, Pisa 56124, Italy.
  • Seco J; Division of BioMedical Physics in Radiation Oncology, German Cancer Research Center, Heidelberg 69120, Germany; Department of Physics and Astronomy, Heidelberg University, Im Neuenheimer Feld 227, Heidelberg 69120, Germany. Electronic address: j.seco@dkfz-heidelberg.de.
  • Voliani V; Center for Nanotechnology Innovation@ NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro, 12, Pisa 56127, Italy; Department of Pharmacy, School of Medical and Pharmaceutical Sciences, University of Genoa, Viale Cembrano, 4, Genoa 16148, Italy. Electronic address: valerio.voliani@unige.it.
Colloids Surf B Biointerfaces ; 245: 114187, 2024 Aug 31.
Article en En | MEDLINE | ID: mdl-39243709
ABSTRACT
Among the tumors with the highest lethality, gliomas are primary brain tumors associated with common recurrence inclined to metastasize along the neuraxis and occasionally out of the central nervous system. Even though metastasis is the main responsible for death in oncological patients, few dedicated treatments are approved. Therefore, the establishment of effective anti-metastasis agents is the final frontier in cancer research. Interestingly, some copper complexes have demonstrated promising efficacy as antimetastatic agents, but they may cause off-site effects such as the alteration of copper homeostasis in healthy tissues. Thus, the incorporation of copper-based antimetastatic agents in rationally designed nano-architectures can increase the treatment localization reducing the side effects. Here, copper complex loaded hybrid nano-architectures (CuLNAs) are presented and employed to assess the impact of an intracellular copper source on glioma cell invasiveness. The novel CuLNAs are fully characterized and exploited for cell migration modulation in a glioma cell line. The results demonstrate that CuLNAs significantly reduce cell migration without impairing cell proliferation compared to standard gold and copper NAs. A concomitant antimigratory-like regulation of the epithelial-to-mesenchymal transition genes confirmed these results, as the gene encoding for the epithelial protein E-cadherin was upregulated and the other explored mesenchymal genes were downregulated. These findings, together with the intrinsic behaviors of NAs, demonstrate that the inclusion of metal complexes in the nano-architectures is a promising approach for the composition of a family of agents with antimetastatic activity.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos