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Immune responses induced by a recombinant C-strain of classical swine fever virus expressing the F317L protein of African swine fever virus.
Li, Shuwen; Gao, Yuxuan; Zhai, Huanjie; Guan, Xiangyu; Yang, Xiaoke; Hou, Qinghe; Zhang, Xinyu; Li, Lian-Feng; Wang, Xiao; Huang, Shujian; Qiu, Hua-Ji; Li, Yongfeng.
Afiliación
  • Li S; State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute, CAAS, 678 Haping Road, Harbin, Heilongjiang 150069, China; College of Life Science and Engineering, Foshan University, 33 Guangyun Road, Foshan, Guangdong 528231, China.
  • Gao Y; State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute, CAAS, 678 Haping Road, Harbin, Heilongjiang 150069, China.
  • Zhai H; State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute, CAAS, 678 Haping Road, Harbin, Heilongjiang 150069, China.
  • Guan X; State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute, CAAS, 678 Haping Road, Harbin, Heilongjiang 150069, China.
  • Yang X; State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute, CAAS, 678 Haping Road, Harbin, Heilongjiang 150069, China.
  • Hou Q; State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute, CAAS, 678 Haping Road, Harbin, Heilongjiang 150069, China.
  • Zhang X; State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute, CAAS, 678 Haping Road, Harbin, Heilongjiang 150069, China; College of Life Science and Engineering, Foshan University, 33 Guangyun Road, Foshan, Guangdong 528231, China.
  • Li LF; State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute, CAAS, 678 Haping Road, Harbin, Heilongjiang 150069, China.
  • Wang X; Department of Pathogenic Biology, School of Basic Medical Sciences, Binzhou Medical University, 346 Guanhai Road, Yantai, Shandong 264000, China. Electronic address: wangxiao2037@126.com.
  • Huang S; College of Life Science and Engineering, Foshan University, 33 Guangyun Road, Foshan, Guangdong 528231, China. Electronic address: sjhuang.foshan@163.com.
  • Qiu HJ; State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute, CAAS, 678 Haping Road, Harbin, Heilongjiang 150069, China; College of Life Science and Engineering, Foshan University, 33 Guangyun Road, Foshan, Guangdong 528231, China. Electronic address: qiuhuaji@
  • Li Y; State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute, CAAS, 678 Haping Road, Harbin, Heilongjiang 150069, China. Electronic address: liyongfeng@caas.cn.
Vet Microbiol ; 298: 110239, 2024 Sep 03.
Article en En | MEDLINE | ID: mdl-39243670
ABSTRACT
African swine fever (ASF), a highly infectious and devastating disease affecting both domestic pigs and wild boars, owes its etiology to African swine fever virus (ASFV). ASFV encodes more than 165 proteins. However, novel immunogenic proteins remain unknown. This study aimed to determine the antigenicity of the F317L protein (pF317L) of ASFV. The results revealed that pF317L was able to react with convalescent pig sera, indicating that pF317L could be a candidate antigen. The antigenic potential of pF317L expressed by rHCLV-F317L, a recombinant virus in the backbone of C-strain (a lapinized live attenuated classical swine fever virus) was further investigated in rabbits and pigs. The results revealed that antibodies and cell-mediated immune responses against pF317L were induced in either rabbits or pigs inoculated with rHCLV-F317L. Importantly, anti-pF317L antibodies from rabbits or pigs immunized with rHCLV-F317L significantly inhibited ASFV replication in vitro. In conclusion, pF317L demonstrates favorable immunogenic properties, positioning it as a promising candidate for the development of protective antigens in the ongoing endeavor to formulate efficacious ASF vaccine strategies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Vet Microbiol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Vet Microbiol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos