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Daily dynamics of resting-state EEG theta and gamma fluctuations are associated with cognitive performance in healthy aging.
Bennis, Kenza; Eustache, Francis; Collette, Fabienne; Vandewalle, Gilles; Hinault, Thomas.
Afiliación
  • Bennis K; Inserm, U1077, EPHE, UNICAEN, Normandie Université, PSL Université Paris, CHU de Caen, GIP Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine (NIMH), 14000 Caen, France.
  • Eustache F; Inserm, U1077, EPHE, UNICAEN, Normandie Université, PSL Université Paris, CHU de Caen, GIP Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine (NIMH), 14000 Caen, France.
  • Collette F; GIGA-CRC-In Vivo Imaging, Université de Liège and Belgian National Fund for Scientific Research, Liège, Belgium.
  • Vandewalle G; GIGA-CRC-In Vivo Imaging, Université de Liège and Belgian National Fund for Scientific Research, Liège, Belgium.
  • Hinault T; Inserm, U1077, EPHE, UNICAEN, Normandie Université, PSL Université Paris, CHU de Caen, GIP Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine (NIMH), 14000 Caen, France.
J Gerontol B Psychol Sci Soc Sci ; 2024 Sep 07.
Article en En | MEDLINE | ID: mdl-39243136
ABSTRACT

OBJECTIVES:

Healthy age-related cognitive changes are highly heterogeneous across individuals. This variability is increasingly explained through the lens of spontaneous fluctuations of brain activity, now considered as powerful index of age-related changes. However, brain activity is a biological process modulated by circadian rhythms, and how these fluctuations evolve throughout the day is under investigated.

METHODS:

We analyzed data from one hundred and one healthy late middle-aged participants from the Cognitive Fitness in Aging study (68 women and 33 men; aged 50-69 years). Participants completed five EEG recordings of spontaneous resting-state activity on the same day. We used weighted phase-lag index (wPLI) analyses as an index of the functional synchrony between brain regions couplings and we computed daily global PLI fluctuation rates of the five recordings to assess the association with cognitive performance and ß-amyloid and tau/neuroinflammation pathological markers.

RESULTS:

We found that theta and gamma daily fluctuations in the salience-control executive inter-network (SN-CEN) are associated with distinct mechanisms underlying cognitive heterogeneity in aging. Higher levels of SN-CEN theta daily fluctuations appear to be deleterious for memory performance and were associated with higher tau/neuroinflammation rates. In contrast, higher levels of gamma daily fluctuations are positively associated with executive performance, and were associated with lower rate of ß-amyloid deposition.

DISCUSSION:

Thus, accounting for daily EEG fluctuations of brain activity contributes to better understand subtle brain changes underlying individuals' cognitive performance in healthy aging. Results also provide arguments for considering time-of-day when assessing cognition for old adults in a clinical context.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Gerontol B Psychol Sci Soc Sci Asunto de la revista: CIENCIAS SOCIAIS / GERIATRIA / PSICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Gerontol B Psychol Sci Soc Sci Asunto de la revista: CIENCIAS SOCIAIS / GERIATRIA / PSICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos