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First hip hemiarthroplasty in a Göttingen Minipig; surgical and post-mortem protocol.
Hartmann, Katrine Top; Odgaard, Anders; Knudsen, Ulrik Kragegaard; Aalbæk, Bent; Kvich, Lasse; Birch, Julie Melsted; Petersen, Andreas; Bjarnsholt, Thomas; Jensen, Henrik Elvang; Jensen, Louise Kruse.
Afiliación
  • Hartmann KT; Department of Veterinary- and Animal Sciences, University of Copenhagen, Grønnegårdsvej 7, 1870, Frederiksberg C, Denmark. katoh@sund.ku.dk.
  • Odgaard A; Department of Orthopedic Surgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
  • Knudsen UK; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Aalbæk B; Department of Orthopedic Surgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
  • Kvich L; Department of Veterinary- and Animal Sciences, University of Copenhagen, Grønnegårdsvej 7, 1870, Frederiksberg C, Denmark.
  • Birch JM; Costerton Biofilm Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
  • Petersen A; Center for Surgical Science, Department of Surgery, Zealand University Hospital, Køge, Denmark.
  • Bjarnsholt T; Department of Veterinary- and Animal Sciences, University of Copenhagen, Grønnegårdsvej 7, 1870, Frederiksberg C, Denmark.
  • Jensen HE; Statens Serum Institut, Artillerivej 5, 2300, Copenhagen S, Denmark.
  • Jensen LK; Costerton Biofilm Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
J Orthop Surg Res ; 19(1): 549, 2024 Sep 06.
Article en En | MEDLINE | ID: mdl-39243099
ABSTRACT

BACKGROUND:

Prosthetic joint infections (PJI) are recalcitrant, hard-to-treat infections and severe complications of joint arthroplasty. Therefore, there is a need to develop new effective treatment strategies, and animal models of high clinical relevance are needed. This study aimed to develop a detailed surgical protocol for hip hemiarthroplasty in Göttingen minipigs and a thorough post-mortem sampling protocol to pave the way for creating a minipig PJI model.

METHODS:

Three adult female Göttingen minipigs underwent surgery with insertion of a hip hemiarthroplasty, using the anterior approach to the hip joint. After surgery the minipigs were followed closely with daily clinical evaluation and gait scoring. Comprehensive post-mortem analyses were performed with evaluation of macroscopic lesions, microbiology, synovial fluid analysis and histology.

RESULTS:

The study resulted in the first Göttingen minipig with hip hemiarthroplasty and identified several points of awareness when inserting a hip prosthesis in minipigs, especially the high risk of joint dislocation. A spontaneous PJI occurred in one of the minipigs, revealing an impaired ability of the immune cells to reach the bacteria at the bone-prosthesis interface.

CONCLUSION:

The present study provides a detailed description of surgical technique and post-mortem sampling and validates the suitability of the hip hemiarthroplasty minipig model for future experimental modeling of PJI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Porcinos Enanos / Infecciones Relacionadas con Prótesis / Artroplastia de Reemplazo de Cadera / Hemiartroplastia Límite: Animals Idioma: En Revista: J Orthop Surg Res Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Porcinos Enanos / Infecciones Relacionadas con Prótesis / Artroplastia de Reemplazo de Cadera / Hemiartroplastia Límite: Animals Idioma: En Revista: J Orthop Surg Res Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido