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Abnormal expression of circ_0013958 in patients with acute myocardial infarction (AMI) and its influence on prognosis.
Sun, Fei; Zou, Shenglan; Li, Xiaomin; Liu, Xueya.
Afiliación
  • Sun F; Department of Cardiology, DeltaHealth Hospital•Shanghai, No. 109, Xule Road, Xujing Town, Qingpu District, Shanghai, 201702, China. sunfeidr@163.com.
  • Zou S; Department of Cardiology, Affiliated Hospital of Yangzhou University, Yangzhou, 225001, China.
  • Li X; Department of Cardiology, DeltaHealth Hospital•Shanghai, No. 109, Xule Road, Xujing Town, Qingpu District, Shanghai, 201702, China.
  • Liu X; Department of Cardiology, DeltaHealth Hospital•Shanghai, No. 109, Xule Road, Xujing Town, Qingpu District, Shanghai, 201702, China.
J Cardiothorac Surg ; 19(1): 517, 2024 Sep 06.
Article en En | MEDLINE | ID: mdl-39243066
ABSTRACT

OBJECTIVE:

The purpose of this study was to investigate the diagnostic value of circ_0013958 in acute myocardial infarction (AMI) patients and its influence on the prognosis of AMI patients.

METHODS:

The GSE160717 dataset was downloaded from the NCBI database and differentially expressed genes were analyzed between the control group and the AMI group. The up-regulated genes included circ_0013958. The expression of circ_0013958 in both groups was further verified by RT-qPCR. The Receiver Operating Characteristic curve was used to evaluate the diagnostic value of circ_0013958 in AMI. Pearson correlation analysis was used to examine the correlation between circ_0013958 levles and biochemical indicators. Binary logistic regression was used to analyze the risk factors affecting the occurrence of AMI. Prognostic analysis was performed using COX regression analysis and the Kaplan-Meier Curve.

RESULTS:

Compared to the control group, the level of circ_0013958 in AMI patients increased. Circ_0013958 can effectively distinguish AMI patients from non-AMI patients. Circ_0013958 levels were positively correlated with cTnI, LDH, CRP and TC levels. The elevated level of circ_0013958 was an independent risk factor for the occurrence of AMI. Higher circ_0013958 levels were also associated with the occurrence of major adverse cardiac events (MACEs) in AMI patients. Additionally, elevated circ_0013958 levels reduced the survival probability of AMI patients.

CONCLUSION:

Circ_0013958 levels were up-regulated in AMI patients. It can be used as a diagnosis biomarker for AMI. The level of circ_0013958 was correlated with the disease severity and was an independent risk factor for the occurrence of AMI. Elevated circ_0013958 levels were associated with poor prognosis in AMI patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Circular / Infarto del Miocardio Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Cardiothorac Surg Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Circular / Infarto del Miocardio Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Cardiothorac Surg Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido