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Increased incidence of neurodegenerative diseases in Finnish individuals with type 1 diabetes.
Satuli-Autere, Susanna; Harjutsalo, Valma; Eriksson, Marika I; Hägg-Holmberg, Stefanie; Öhman, Hanna; Claesson, Tor-Björn; Groop, Per-Henrik; Thorn, Lena M.
Afiliación
  • Satuli-Autere S; Folkhälsan Research Center, Helsinki, Finland.
  • Harjutsalo V; Department of General Practice and Primary Health Care, Helsinki University Central Hospital, Helsinki, Finland.
  • Eriksson MI; Folkhälsan Research Center, Helsinki, Finland.
  • Hägg-Holmberg S; Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland.
  • Öhman H; Folkhälsan Research Center, Helsinki, Finland.
  • Claesson TB; Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland.
  • Groop PH; Folkhälsan Research Center, Helsinki, Finland.
  • Thorn LM; Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland.
BMJ Open Diabetes Res Care ; 12(4)2024 Sep 05.
Article en En | MEDLINE | ID: mdl-39242121
ABSTRACT

INTRODUCTION:

Diabetes is linked to neurodegenerative diseases (NDs), but data in type 1 diabetes are scarce. Our aim was to assess the standardized incidence ratios (SIRs) of different NDs in type 1 diabetes, and to evaluate the impact of diabetic vascular complications and age at diabetes onset. RESEARCH DESIGN AND

METHODS:

In this observational cohort study, we included 4261 individuals with type 1 diabetes from the Finnish Diabetic Nephropathy study, and 11 653 matched population-based controls without diabetes. NDs were identified from registers until the end of 2017. Diabetic complications were assessed at the baseline study visit. SIRs were calculated from diabetes onset, except for impact of complications that was calculated from baseline study visit.

RESULTS:

The SIRs for NDs were increased in type 1 diabetes any dementia 2.24 (95% CI 1.79 to 2.77), Alzheimer's disease 2.13 (95% CI 1.55 to 2.87), vascular dementia 3.40 (95% CI 2.08 to 5.6), other dementias 1.70 (95% CI 1.22 to 2.31), and Parkinson's disease 1.61 (95% CI 1.04 to 2.37). SIR showed a twofold increased incidence already in those without albuminuria (1.99 (1.44-2.68)), but further increased in presence of diabetic complications kidney disease increased SIR for Alzheimer's disease, while cardiovascular disease increased SIR for both Alzheimer's disease and other dementias. Diabetes onset <15 years, compared with ≥15 years, increased SIR of Alzheimer's disease, 3.89 (2.21-6.35) vs 1.73 (1.16-2.48), p<0.05, but not the other dementias.

CONCLUSIONS:

ND incidence is increased 1.7-3.4-fold in type 1 diabetes. The presence of diabetic kidney disease and cardiovascular disease further increased the incidence of dementia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Diabetes Mellitus Tipo 1 Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: BMJ Open Diabetes Res Care Año: 2024 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Diabetes Mellitus Tipo 1 Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: BMJ Open Diabetes Res Care Año: 2024 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido