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Evaluation of clinical outcomes of anidulafungin for the treatment of candidemia in hospitalized critically ill patients with obesity: A multicenter, retrospective cohort study.
Alsowaida, Yazed Saleh; Sulaiman, Khalid Al; Mahrous, Ahmad J; Alharbi, Aisha; Bifari, Nisrin; Alshahrani, Walaa A; Almangour, Thamer A; Damfu, Nader; Banamah, Aseel A; Raya, Raghad R Abu; Sadawi, Raghad A; Alharbi, Arwa; Alsolami, Ahmed; Essa, Yahya; Almagthali, Alaa Ghaze; Alhejaili, Shahad F; Qawwas, Wed A; Alharbi, Ghaida Salamah; Alkeraidees, Atheer Suleiman; Alshomrani, Afnan; Aljohani, Manal A; Aljuhani, Ohoud.
Afiliación
  • Alsowaida YS; Department of Clinical Pharmacy, College of Pharmacy, University of Hail, Hail 55473, Saudi Arabia.
  • Sulaiman KA; Pharmaceutical Care Services, King Abdulaziz Medical City, Riyadh, Saudi Arabia; College of Pharmacy, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Saudi Critical Care Pharmacy Research (SCAPE)
  • Mahrous AJ; Pharmacy Practices Department, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
  • Alharbi A; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Pharmaceutical Care Department, King Abdulaziz Medical City, Jeddah, Saudi Arabia; King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
  • Bifari N; Pharmacy Practices Department, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
  • Alshahrani WA; Pharmacist, Alshafi Medical Company, Riyadh, Saudi Arabia.
  • Almangour TA; Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
  • Damfu N; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Infection Prevention and Control Department, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia; King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
  • Banamah AA; College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
  • Raya RRA; College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
  • Sadawi RA; College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
  • Alharbi A; Pharmaceutical Care Department, King Abdulaziz Medical City, Jeddah, Saudi Arabia.
  • Alsolami A; Department of Internal Medicine, College of Medicine, University of Ha'il, Ha'il, Saudi Arabia.
  • Essa Y; Pharmaceutical Care Department, King Abdulaziz Medical City, Jeddah, Saudi Arabia.
  • Almagthali AG; Pharmaceutical Care Department, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Alhejaili SF; Pharmaceutical Care Services, King Abdulaziz University Hospital, Jeddah, Saudi Arabia; Pharmaceutical Care Services, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia.
  • Qawwas WA; Department of Pharmaceutical Care Services, King Abdullah Medical City, Makkah, Saudi Arabia.
  • Alharbi GS; Department of Pharmaceutical Care Services, King Abdullah Medical City, Makkah, Saudi Arabia.
  • Alkeraidees AS; Pharmaceutical Care Services, King Abdulaziz Medical City, Ministry of National Guard Health Affairs (MNGHA), Riyadh, Saudi Arabia.
  • Alshomrani A; Pharmaceutical Care Department, King Abdulaziz Medical City, Jeddah, Saudi Arabia.
  • Aljohani MA; Pharmaceutical Care Services, King Abdulaziz Medical City, Riyadh, Saudi Arabia; College of Pharmacy, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
  • Aljuhani O; Department of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Int J Infect Dis ; 148: 107234, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39241957
ABSTRACT

OBJECTIVES:

To evaluate the clinical outcomes of anidulafungin for candidemia treatment in critically ill patients with obesity.

METHODS:

A multicenter, retrospective cohort study was conducted in Saudi Arabia for critically ill adults with candidemia who received anidulafungin. Patients with obesity have a body mass index ≥30 kg/m2. The primary outcome was the clinical cure rate.

RESULTS:

A total of 146 patients were included, 64 of whom were obese. There were no statistically significant differences in the clinical cure rate (P = 0.63), microbiological cure rate (P = 0.27), or the median time for a clinical cure (P = 0.13) for patients with obesity compared to non-obese patients. The median time for a microbiological cure was longer in non-obese patients than in patients with obesity (P = 0.04). The median hospital length of stay and the median mechanical ventilation durations were numerically longer in patients with obesity.

CONCLUSIONS:

Clinical and microbiological cure rates and time for clinical cure were statistically similar for both groups. Considering the study's limitations (especially with a small sample size), it is uncertain if patients with obesity have similar effectiveness to non-obese patients. Future studies with larger sample sizes are warranted to evaluate if obesity negatively impacts anidulafungin's clinical outcomes for candidemia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Crítica / Candidemia / Anidulafungina / Antifúngicos / Obesidad Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Int J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Canadá
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Crítica / Candidemia / Anidulafungina / Antifúngicos / Obesidad Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Int J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Canadá