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Physical and psychological distress amongst patients undergoing neoadjuvant chemotherapy for advanced ovarian cancer.
Mokshagundam, Shilpa; McGree, Michaela E; Tapia, Amanda L; Fought, Angela J; Ishitani, Karen P; Lee, Minji K; Dowdy, Sean C; Yadav, Siddhartha; Pachman, Deirdre R; Kumar, Amanika.
Afiliación
  • Mokshagundam S; Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, United States of America. Electronic address: Mokshagundam.Shilpa@mayo.edu.
  • McGree ME; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, United States of America.
  • Tapia AL; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, United States of America.
  • Fought AJ; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, United States of America.
  • Ishitani KP; Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, United States of America.
  • Lee MK; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, United States of America.
  • Dowdy SC; Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, United States of America; Robert D. and Patricia E. Kern Center for the Science of Healthcare Delivery, Mayo Clinic, Rochester, MN, United States of America.
  • Yadav S; Department of Oncology, Mayo Clinic, Rochester, MN, United States of America.
  • Pachman DR; Division of Community Internal Medicine, Geriatrics, and Palliative Care, Department of Medicine, Mayo Clinic, Rochester, MN, United States of America.
  • Kumar A; Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, United States of America.
Gynecol Oncol ; 190: 230-235, 2024 Sep 05.
Article en En | MEDLINE | ID: mdl-39241618
ABSTRACT

OBJECTIVE:

This study compares baseline clinical characteristics, physical function testing, and patient-reported outcomes for patients undergoing primary cytoreductive surgery versus neoadjuvant chemotherapy, with the goal of better understanding unique patient needs at diagnosis.

METHODS:

Patients with suspected advanced stage (IIIC/IV) epithelial ovarian cancer undergoing either primary cytoreductive surgery or neoadjuvant chemotherapy were enrolled in a single-institution, non-randomized prospective behavioral intervention trial of prehabilitation. Baseline clinical characteristics were abstracted. Physical function was evaluated using the Short Physical Performance Battery, Fried Frailty Index, gait speed, and grip strength. Patient-reported outcomes were evaluated using Patient-Reported Outcomes Measurement Information System metrics and the Perceived Stress Scale.

RESULTS:

There were no significant differences in demographics or clinical characteristics between cohorts at enrollment, with the exception of performance status, clinical stage, and albumin. While gait speed and grip strength were lower amongst neoadjuvant chemotherapy patients, there were no significant differences in physical function using the Short Physical Performance Battery and Fried Frailty Index. Patients in the neoadjuvant chemotherapy cohort reported decreased perception of physical function and increased fatigue on Patient-Reported Outcomes Measurement Information System metrics. A larger proportion of patients in the neoadjuvant cohort reported severe levels of emotional distress and anxiety, as well as greater perceived stress at diagnosis.

CONCLUSIONS:

Our findings suggest that patients undergoing neoadjuvant chemotherapy for advanced ovarian cancer present with increased psychosocial distress and decreased perception of physical function at diagnosis and may benefit most from early introduction of supportive care.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Gynecol Oncol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Gynecol Oncol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos