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MSCs biomimetic ultrasonic phase change nanoparticles promotes cardiac functional recovery after acute myocardial infarction.
Wang, Zhuo; Chen, Jianfeng; Wang, Jiaxu; Xu, Mingyuan; Yang, Haichao; Yang, Haobo; Zhao, Chen; Sun, Ping; Ji, Huan; Liu, Jinhong; Shan, Jiaxin; Tian, Jiawei; Li, Shouqiang; Yu, Dandan; Wang, Chao; Yu, Xinhong; Ding, Shuo; Xu, Wenjun; Zhang, Ying; Leng, Xiaoping; R-Porter, Thomas.
Afiliación
  • Wang Z; Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China; Ultrasound Molecular Imaging Joint Laboratory of Heilongjiang Province (International Cooperation), Harbin, 150086, China; Key Laboratories of Myocardial Ischemia, Harbin Medical University,
  • Chen J; Laboratory Animal Center, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
  • Wang J; Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China; Ultrasound Molecular Imaging Joint Laboratory of Heilongjiang Province (International Cooperation), Harbin, 150086, China; Key Laboratories of Myocardial Ischemia, Harbin Medical University,
  • Xu M; Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China; Ultrasound Molecular Imaging Joint Laboratory of Heilongjiang Province (International Cooperation), Harbin, 150086, China.
  • Yang H; Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China; Ultrasound Molecular Imaging Joint Laboratory of Heilongjiang Province (International Cooperation), Harbin, 150086, China; Key Laboratories of Myocardial Ischemia, Harbin Medical University,
  • Yang H; Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China; Ultrasound Molecular Imaging Joint Laboratory of Heilongjiang Province (International Cooperation), Harbin, 150086, China; Key Laboratories of Myocardial Ischemia, Harbin Medical University,
  • Zhao C; Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China; Ultrasound Molecular Imaging Joint Laboratory of Heilongjiang Province (International Cooperation), Harbin, 150086, China.
  • Sun P; Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China; Ultrasound Molecular Imaging Joint Laboratory of Heilongjiang Province (International Cooperation), Harbin, 150086, China; Key Laboratories of Myocardial Ischemia, Harbin Medical University,
  • Ji H; Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
  • Liu J; Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China; Ultrasound Molecular Imaging Joint Laboratory of Heilongjiang Province (International Cooperation), Harbin, 150086, China.
  • Shan J; Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China; Ultrasound Molecular Imaging Joint Laboratory of Heilongjiang Province (International Cooperation), Harbin, 150086, China.
  • Tian J; Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China; Ultrasound Molecular Imaging Joint Laboratory of Heilongjiang Province (International Cooperation), Harbin, 150086, China.
  • Li S; Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China; Ultrasound Molecular Imaging Joint Laboratory of Heilongjiang Province (International Cooperation), Harbin, 150086, China.
  • Yu D; Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
  • Wang C; Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
  • Yu X; Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
  • Ding S; Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
  • Xu W; Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
  • Zhang Y; Ultrasound Imaging Department of the Second Affiliated Hospital of Harbin Medical University, and Pharmacology Department of Pharmacy College of Harbin Medical University, Harbin, 150081, China. Electronic address: jennying223@126.com.
  • Leng X; Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China; Ultrasound Molecular Imaging Joint Laboratory of Heilongjiang Province (International Cooperation), Harbin, 150086, China. Electronic address: xpleng@ems.hrbmu.edu.cn.
  • R-Porter T; Department of Cardiology, University of Nebraska Medical Center, Omaha, NE, NE 68198, USA.
Biomaterials ; 313: 122775, 2025 Feb.
Article en En | MEDLINE | ID: mdl-39241549
ABSTRACT
Acute Myocardial Infarction (AMI) has seen rising cases, particularly in younger people, leading to public health concerns. Standard treatments, like coronary artery recanalization, often don't fully repair the heart's microvasculature, risking heart failure. Advances show that Mesenchymal Stromal Cells (MSCs) transplantation improves cardiac function after AMI, but the harsh microenvironment post-AMI impacts cell survival and therapeutic results. MSCs aid heart repair via their membrane proteins and paracrine extracellular vesicles that carry microRNA-125b, which regulates multiple targets, preventing cardiomyocyte death, limiting fibroblast growth, and combating myocardial remodeling after AMI. This study introduces ultrasound-responsive phase-change bionic nanoparticles, leveraging MSCs' natural properties. These particles contain MSC membrane and microRNA-125b, with added macrophage membrane for stability. Using Ultrasound Targeted Microbubble Destruction (UTMD), this method targets the delivery of MSC membrane proteins and microRNA-125b to AMI's inflamed areas. This aims to enhance cardiac function recovery and provide precise, targeted AMI therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs / Nanopartículas / Células Madre Mesenquimatosas / Infarto del Miocardio Límite: Animals / Humans / Male Idioma: En Revista: Biomaterials Año: 2025 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs / Nanopartículas / Células Madre Mesenquimatosas / Infarto del Miocardio Límite: Animals / Humans / Male Idioma: En Revista: Biomaterials Año: 2025 Tipo del documento: Article Pais de publicación: Países Bajos