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Tailored NADES solvents for the extraction optimization of benzylisoquinoline alkaloids from Thalictrum foliolosum DC.- A potential phyto-nutraceutical source.
Singh, Basant; Singh, Laxman; Bhatt, Indra D; Kandpal, Narain D.
Afiliación
  • Singh B; Center for Biodiversity Conservation and Management, G. B. Pant National Institute of Himalayan Environment, Kosi-Katarmal, Almora, Uttarakhand, India.
  • Singh L; Center for Biodiversity Conservation and Management, G. B. Pant National Institute of Himalayan Environment, Kosi-Katarmal, Almora, Uttarakhand, India.
  • Bhatt ID; Center for Biodiversity Conservation and Management, G. B. Pant National Institute of Himalayan Environment, Kosi-Katarmal, Almora, Uttarakhand, India. Electronic address: idbhatt@gbpihed.nic.in.
  • Kandpal ND; Department of Chemistry, S. S. J. Campus, Soban Singh Jeena University Almora, India.
Food Chem ; 463(Pt 1): 141016, 2024 Aug 30.
Article en En | MEDLINE | ID: mdl-39241417
ABSTRACT
From a perspective focused on phyto-nutraceuticals, alkaloids are considered to be the most significant metabolites, as they exhibit a broad range of pharmacological applications. Therefore, it is essential, to conduct a thorough investigation of the extraction techniques employed and to optimize the overall process. Considering this, we delved into tailor-made natural deep eutectic solvents coupled with ultrasonic-assisted extraction and macroporous resins aided recovery of therapeutics alkaloids from Thalictrum foliolosum DC. The extraction parameters including duty cycle (X1), extraction time (X2), water content (X3), and liquid-to-solid ratio (X4) were optimized through response surface methodology. Under the optimal extraction conditions [duty cycle- 61 %, ultrasonication extraction time- 10.35 min, water content- 30.51 %, and liquid-to-solid ratio- 30 mL/g], the yield of berberine (11.91 ± 0.12 mg/g DW), berbamine (11.85 ± 0.16 mg/g DW), magnoflorine (6.06 ± 0.05 mg/g DW), and palmatine (2.53 ± 0.015 mg/g DW) were found to be near the model prediction. Further, adsorption/desorption characteristics were investigated, and the results highlight AB-8 resin as most effective for the recovery of berberine and palmatine, while, XAD-7HP resin is best suited for berbamine and magnoflorine. FT-IR analysis shows similar spectra among the purified extracts with significantly (p < 0.05) higher antioxidant and anti-glycemic activities. In conclusion, the developed method complies with the criteria of green extraction which can be harnessed as a natural antioxidant in pharmaceutical and nutraceutical industries.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Food Chem Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Food Chem Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido