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rTMS mechanisms for posttraumatic stress disorder treatment in a mouse model.
Claverie, Damien; Cressant, Arnaud; Thomasson, Julien; Castellarin, Cédric; Grandperret, Vincent; Barbier, Laure; Troubat, Romain; Canini, Frédéric; Belzung, Catherine; El-Hage, Wissam.
Afiliación
  • Claverie D; Unité de Neurophysiologie du Stress, Département Neurosciences & Contraintes Opérationnelles, Institut de Recherche Biomédicale des Armées (IRBA), Brétigny-sur-Orge, France; Réseau ABC des Psychotraumas, France(2). Electronic address: claveriedamien@hotmail.com.
  • Cressant A; Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, Tours, France; Equipe Neurobiologie de la prise de décision, Département Neurosciences cognitives et des réseaux, Institut des Neurosciences de Paris-Saclay, Saclay, France.
  • Thomasson J; Unité de Neurophysiologie du Stress, Département Neurosciences & Contraintes Opérationnelles, Institut de Recherche Biomédicale des Armées (IRBA), Brétigny-sur-Orge, France.
  • Castellarin C; Unité d'Imagerie, Département Plateformes et Recherche Technologique, Institut de Recherche Biomédicale des Armées (IRBA), Brétigny-sur-Orge, France.
  • Grandperret V; Unité de Biologie Moléculaire, Département Plateformes et Recherche Technologique, Institut de Recherche Biomédicale des Armées (IRBA), Brétigny-sur-Orge, France.
  • Barbier L; Unité de Biologie Moléculaire, Département Plateformes et Recherche Technologique, Institut de Recherche Biomédicale des Armées (IRBA), Brétigny-sur-Orge, France.
  • Troubat R; Unité de Neurophysiologie du Stress, Département Neurosciences & Contraintes Opérationnelles, Institut de Recherche Biomédicale des Armées (IRBA), Brétigny-sur-Orge, France; Réseau ABC des Psychotraumas, France(2); Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, To
  • Canini F; Laboratoire Inter-Universitaire de Psychologie. Personnalité, Cognition, Changement Social (LIP - PC2S), Université Grenoble Alpes, Université Savoie Mont Blanc, Grenoble, France.
  • Belzung C; Réseau ABC des Psychotraumas, France(2); Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, Tours, France.
  • El-Hage W; Réseau ABC des Psychotraumas, France(2); Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, Tours, France.
J Psychiatr Res ; 179: 33-43, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39241409
ABSTRACT

BACKGROUND:

Posttraumatic stress disorder (PTSD) is a psychiatric disease that may follow traumatic exposure. Current treatments fail in about 30% of patients. Although repeated transcranial magnetic stimulation (rTMS) applied to the prefrontal cortex has been shown to be effective in the treatment of PTSD, the mechanisms need further investigation.

OBJECTIVE:

Using a PTSD animal model, we verify the beneficial effect of rTMS, and explore the changes it induces on two putative PTSD mechanisms, GABA/glutamate neurotransmission and neuroinflammation.

METHODS:

PTSD-like symptoms were elicited in twenty-six mice using a foot-shock conditioning procedure. Fourteen of the 26 were then treated using rTMS (12 were untreated). In the control group (n = 30), 18 were treated with rTMS and 12 were untreated. Animals were sacrificed after re-exposure. The infralimbic (IL) cortex, basolateral amygdala (BLA) and ventral CA1 (vCA1) were isolated using laser microdissection. mRNA was then investigated using PCR array analysis targeting GABA/glutamate and inflammatory pathways.

RESULTS:

The rTMS treatment significantly decreased the contextual fear memory phenotype. These changes were associated with reduced mRNA expression related to inflammation in the IL cortex and the vCA1, and lowered mRNA-related glutamate neurotransmission and increased GABA neurotransmission in the BLA.

CONCLUSION:

Our results suggest that our rTMS treatment was associated with local anti-inflammatory effects and limbic effects, which seemed to counteract PTSD effects. Several of these changes (both stress- and rTMS-induced) have implications for the drug sensitivity of limbic brain areas, and may help in the design of future therapeutic protocols.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Modelos Animales de Enfermedad / Estimulación Magnética Transcraneal Límite: Animals Idioma: En Revista: J Psychiatr Res Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Modelos Animales de Enfermedad / Estimulación Magnética Transcraneal Límite: Animals Idioma: En Revista: J Psychiatr Res Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido