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A multi-pronged approach to assessing antimicrobial resistance risks in coastal waters and aquaculture systems.
Goh, Shin Giek; You, Luhua; Ng, Charmaine; Tong, Xuneng; Mohapatra, Sanjeeb; Khor, Wei Ching; Ong, Hong Ming Glendon; Aung, Kyaw Thu; Gin, Karina Yew-Hoong.
Afiliación
  • Goh SG; NUS Environmental Research Institute, National University of Singapore, 1 Create way, Create Tower, #15-02, Singapore 138602, Singapore.
  • You L; NUS Environmental Research Institute, National University of Singapore, 1 Create way, Create Tower, #15-02, Singapore 138602, Singapore.
  • Ng C; NUS Environmental Research Institute, National University of Singapore, 1 Create way, Create Tower, #15-02, Singapore 138602, Singapore.
  • Tong X; NUS Environmental Research Institute, National University of Singapore, 1 Create way, Create Tower, #15-02, Singapore 138602, Singapore.
  • Mohapatra S; NUS Environmental Research Institute, National University of Singapore, 1 Create way, Create Tower, #15-02, Singapore 138602, Singapore.
  • Khor WC; National Centre for Food Science, Singapore Food Agency, 7 International Business Park, Singapore 609919, Singapore.
  • Ong HMG; National Centre for Food Science, Singapore Food Agency, 7 International Business Park, Singapore 609919, Singapore.
  • Aung KT; National Centre for Food Science, Singapore Food Agency, 7 International Business Park, Singapore 609919, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore; Department of Food Science and Technology, National University of Singapore, Singapore 11
  • Gin KY; NUS Environmental Research Institute, National University of Singapore, 1 Create way, Create Tower, #15-02, Singapore 138602, Singapore; Department of Civil & Environmental Engineering, National University of Singapore, 1 Engineering Drive 2, Singapore 117576, Singapore. Electronic address: ceeg
Water Res ; 266: 122353, 2024 Aug 28.
Article en En | MEDLINE | ID: mdl-39241380
ABSTRACT
Antimicrobial resistance (AMR) is a global challenge that has impacted aquaculture and surrounding marine environments. In this study, a year-long monitoring program was implemented to evaluate AMR in two different aquaculture settings (i.e., open cage farming, recirculating aquaculture system (RAS)) and surrounding marine environment within a tropical coastal region. The objectives of this study are to (i) investigate the prevalence and co-occurrence of antibiotic-resistant bacteria (ARB), antibiotic resistance genes (ARGs), antibiotics (AB) and various associated chemical compounds at these study sites; (ii) explore the contributing factors to development and propagation of AMR in the coastal environment; and (iii) assess the AMR risks from different perspectives based on the three AMR determinants (i.e., ARB, ARGs and AB). Key findings revealed a distinct pattern of AMR across the different aquaculture settings, notably a higher prevalence of antibiotic-resistant Vibrio at RAS outfalls, suggesting a potential accumulation of microorganisms within the treatment system. Despite the relative uniform distribution of ARGs across marine sites, specific genes such as qepA, blaCTX-M and bacA, were found to be abundant in fish samples, especially from the RAS. Variations in chemical contaminant prevalence across sites highlighted possible anthropogenic impacts. Moreover, environmental and seasonal variations were found to significantly influence the distribution of ARGs and chemical compounds in the coastal waters. Hierarchical cluster analysis that was based on ARGs, chemical compounds and environmental data, categorized the sites into three distinct clusters which reflected strong association with location, seasonality and aquaculture activities. The observed weak correlations between ARGs and chemical compounds imply that low environmental concentrations may be insufficient for resistance selection. A comprehensive risk assessment using methodologies such as the multiple antibiotic resistance (MAR) index, comparative AMR risk index (CAMRI) and Risk quotient (RQ) underscored the complexity of AMR risks. This research significantly contributes to the understanding of AMR dynamics in natural aquatic systems and provides valuable insights for managing and mitigating AMR risks in coastal environments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Water Res Año: 2024 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Water Res Año: 2024 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Reino Unido