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Comparative analysis of noise and music exposure on inflammatory responses on lipopolysaccharide-induced septic rats.
Liu, Hu; Peng, Xing-Guo; Gao, Ran; Yang, Kai; Zhao, Yan-Bo.
Afiliación
  • Liu H; Department of Emergency and Critical Care Center, Renmin Hospital, Hubei University of Medicine, Hubei, China.
  • Peng XG; Department of Emergency and Critical Care Center, Renmin Hospital, Hubei University of Medicine, Hubei, China.
  • Gao R; Department of Emergency and Critical Care Center, Renmin Hospital, Hubei University of Medicine, Hubei, China.
  • Yang K; Department of Emergency and Critical Care Center, Renmin Hospital, Hubei University of Medicine, Hubei, China.
  • Zhao YB; Department of Emergency and Critical Care Center, Renmin Hospital, Hubei University of Medicine, Hubei, China.
Hum Exp Toxicol ; 43: 9603271241282584, 2024.
Article en En | MEDLINE | ID: mdl-39240701
ABSTRACT

OBJECTIVE:

Environmental factors such as noise and music can significantly impact physiological responses, including inflammation. This study explored how environmental factors like noise and music affect lipopolysaccharide (LPS)-induced inflammation, with a focus on systemic and organ-specific responses. MATERIALS AND

METHODS:

24 Wistar rats were divided into four groups (n = 6 per group) Control group, LPS group, noise-exposed group, and music-exposed group. All rats, except for the Control group, received 10 mg/kg LPS intraperitoneally. The rats in the noise-exposed group were exposed to 95 dB noise, and the music-exposed group listened to Mozart's K. 448 music (65-75 dB) for 1 h daily over 7 days. An enzyme-linked immunosorbent assay was utilized to detect the levels of inflammatory cytokines, including tumor necrosis factor-α (TNF-α) and interleukin-1ß (IL-1ß), in serum and tissues (lung, liver, and kidney). Western blot examined the phosphorylation levels of nuclear factor-κB (NF-κB) p65 in organ tissues.

RESULTS:

Compared with the Control group, LPS-induced sepsis rats displayed a significant increase in the levels of TNF-α and IL-1ß in serum, lung, liver, and kidney tissues, as well as a remarkable elevation in the p-NF-κB p65 protein expression in lung, liver, and kidney tissues. Noise exposure further amplified these inflammatory markers, while music exposure reduced them in LPS-induced sepsis rats.

CONCLUSION:

Noise exposure exacerbates inflammation by activating the NF-κB pathway, leading to the up-regulation of inflammatory markers during sepsis. On the contrary, music exposure inhibits NF-κB signaling, indicating a potential therapeutic effect in reducing inflammation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lipopolisacáridos / Ratas Wistar / Sepsis / Música / Ruido Límite: Animals Idioma: En Revista: Hum Exp Toxicol Asunto de la revista: TOXICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lipopolisacáridos / Ratas Wistar / Sepsis / Música / Ruido Límite: Animals Idioma: En Revista: Hum Exp Toxicol Asunto de la revista: TOXICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido