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Aflatoxin exposure is associated with an increased risk of gallbladder cancer.
Yadav, Amit; Gupta, Pankaj; Gupta, Parikshaa; Patil, Amol N; Das, Chandan K; Hooda, Harish; Thakur, Deepa; Sharma, Vishal; Singh, Anupam K; Yadav, Thakur Deen; Kaman, Lileswar; Thakur, Jarnail Singh; Sudini, Hari Kishan; Srinivasan, Radhika; Dutta, Usha.
Afiliación
  • Yadav A; Department of Gastroenterology, PGIMER, Chandigarh, India.
  • Gupta P; Department of Radiology, PGIMER, Chandigarh, India.
  • Gupta P; Department of Cytology & Gynecological Pathology, PGIMER, Chandigarh, India.
  • Patil AN; Department of Clinical Pharmacology, PGIMER, Chandigarh, India.
  • Das CK; Department of Medical Oncology, PGIMER, Chandigarh, India.
  • Hooda H; Department of Gastroenterology, PGIMER, Chandigarh, India.
  • Thakur D; Department of Gastroenterology, PGIMER, Chandigarh, India.
  • Sharma V; Department of Gastroenterology, PGIMER, Chandigarh, India.
  • Singh AK; Department of Gastroenterology, PGIMER, Chandigarh, India.
  • Yadav TD; Department of Surgery, PGIMER, Chandigarh, India.
  • Kaman L; Department of Surgery, PGIMER, Chandigarh, India.
  • Thakur JS; Department of Community Medicine and School of Public Health, PGIMER, Chandigarh, India.
  • Sudini HK; International Crops Research Institute for the Semi-Arid Tropics Patancheru, Hyderabad, India.
  • Srinivasan R; Department of Cytology & Gynecological Pathology, PGIMER, Chandigarh, India.
  • Dutta U; Department of Gastroenterology, PGIMER, Chandigarh, India.
Int J Cancer ; 2024 Sep 06.
Article en En | MEDLINE | ID: mdl-39239866
ABSTRACT
Gall bladder cancer (GBC) is common among the socioeconomically deprived populations of certain geographical regions. Aflatoxin is a genotoxic hepatocarcinogen, which is recognized to have a role in the pathogenesis of hepatocellular carcinoma. However, the role of aflatoxin in the pathogenesis of GBC is largely unknown. We determined serum AFB1-Lys albumin adduct (AAA) levels as a marker of aflatoxin exposure in the patients with GBC and compared to those without GBC. The relationship of AAA levels to cytogenetic (TP53mutation&HER2/neu amplification) and radiological characteristics of the tumor was assessed. We included GBC cases (n = 51) and non-GBC controls (n = 100). Mean serum AAA levels were higher in the GBC group (n = 51) than those without GBC (n = 100) (26.1 ± 12.2 vs. 13.1 ± 11.9 ng/mL; p < .001). HER2/neu expression was associated with higher AAA levels compared to those with equivocal or negative expression (43.9 ± 3 vs. 28.6 ± 10 vs. 19.3 ± 7 ng/mL; p < .001). Older age (age >50 years) (odds ratio [OR] = 3.2 [CI 1.3-8.2]; p = .013), positive Helicobacter pylori serology (OR = 5.1 [CI 1.4-17.8]; p = .012), presence of GS (OR = 5 [CI 1.5-16.9]; p = .009) and detectable AAA levels (OR = 6.8 [CI 1.3-35.7]; p = .024) were independent risk factors for the presence of the GBC among all study subjects. Among patients harboring GS, older age (age >50 years) (OR = 4.5 [CI 1.3-14.9]; p = .015), female gender (OR = 3.8 [CI 1.2-12.5]; p = .027), presence of multiple GS (OR = 21.9 [CI 4.8-100.4]; p < .001) and high serum AAA levels (OR = 5.3 [CI 1.6-17.3]; p = .006) were independent risk factors for the presence of the GBC. Elderly age >50 years (OR = 2.6 [CI 1.3-5.2]; p = .010) and frequent peanut consumption (OR = 2.3 [CI 1.1-4.9]; p = .030) were independent risk factors for high serum AAA levels. The current study has implications for the prevention of GBC through the reduction of dietary aflatoxin exposure.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Cancer Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Cancer Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos