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Iron-Chelating Hydroxyketone Ligands Promote Degradation of Fe(III)-Tannic Acid Nanofilms.
Joo, Hyejin; Kim, Seulbi; Park, Kyungran; Jang, Seong Yoon; Kang, Kyungtae; Kim, Hyungjun; Park, Ji Hun.
Afiliación
  • Joo H; Department of Science Education, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Republic of Korea.
  • Kim S; Department of Science Education, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Republic of Korea.
  • Park K; Ecogear Inc., 52, Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Republic of Korea.
  • Jang SY; Department of Science Education, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Republic of Korea.
  • Kang K; Department of Science Education, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Republic of Korea.
  • Kim H; Department of Applied Chemistry, Kyung Hee University, Yongin, Gyeonggi, 17104, Republic of Korea.
  • Park JH; Department of Chemistry, Incheon National University, Incheon, 22012, Republic of Korea.
Chem Asian J ; : e202400864, 2024 Sep 05.
Article en En | MEDLINE | ID: mdl-39238279
ABSTRACT
Polyphenols form nanofilms with transition metal ions by coordination-driven assembly. The as-formed metal-polyphenol nanofilms can degrade in the presence of chelating ligands that exhibit high stability constant with the nanofilm-forming metal ions. We have demonstrated the degradation of Fe(III)-tannic acid nanofilms with hydroxyketone ligands, such as maltol, kojic acid, and deferiprone, which exhibit high availability and excellent cytocompatibility. The concentration screening experiments have been performed with different ligand concentrations ranging from 1 mM-25 mM. It is important to note that only deferiprone degrades Fe(III)-TA nanofilms even at 1 mM, and it retains the degradation activity at pH 7.4. The characteristic degradation activity of hydroxyketone ligands to Fe(III)-TA nanofilms may depend upon their pKa value and stability constant. The degradation studies herein are attractive for the development of biomedical applications utilizing metal-polyphenol nanofilms as a sacrificial template.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Asian J Año: 2024 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Asian J Año: 2024 Tipo del documento: Article Pais de publicación: Alemania