Gold-Catalyzed Alkyne Oxidative Cyclization/Mannich-Type Addition Cascade Reaction of Ynamides with 1,3,5-Triazinanes.

Chen, Kewei; Li, Chao; Dong, Shanliang; Hong, Kemiao; Huang, Jingjing; Xu, Xinfang

Chen, Kewei; Li, Chao; Dong, Shanliang; Hong, Kemiao; Huang, Jingjing; Xu, Xinfang.

Afiliación

Chen K; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, Guangdong, China.
Li C; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, Guangdong, China.
Dong S; School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Hong K; School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Huang J; School of Chemistry, Sun Yat-sen University, Guangzhou 510006, Guangdong, China.
Xu X; School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.

J Org Chem ; 89(18): 13623-13628, 2024 Sep 20.

Article en En | MEDLINE | ID: mdl-39238209

ABSTRACT

ABSTRACT

Herein, a gold-catalyzed alkyne oxidative cyclization/Mannich-type addition cascade reaction of ynamides with 1,3,5-triazinanes in the presence of a Brønsted acid has been presented. A class of functionalized fluorenes bearing a quaternary carbon center was synthesized directly with moderate to excellent yields via in situ formed α-oxo carbenes using quinoline N-oxide as the oxidant under mild reaction conditions.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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