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Biomechanical changes of tree shrew posterior sclera during experimental myopia, after retrobulbar vehicle injections, and crosslinking using genipin.
Bianco, Gianfranco; Girkin, Christopher A; Samuels, Brian C; Fazio, Massimo A; Grytz, Rafael.
Afiliación
  • Bianco G; Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL, 35294, USA. gbianco@uabmc.edu.
  • Girkin CA; Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
  • Samuels BC; Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
  • Fazio MA; Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
  • Grytz R; Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Sci Rep ; 14(1): 20667, 2024 09 05.
Article en En | MEDLINE | ID: mdl-39237593
ABSTRACT
Myopia is a common ocular condition characterized by biomechanical weakening revealed by increasing creep rate, cyclic softening scleral thinning, change of collagen fibril crimping, and excessive elongation of the posterior sclera resulting in blurred vision. Animal studies support scleral crosslinking as a potential treatment for myopia control by strengthening the weakened sclera and slowing scleral expansion. While multiple studies investigated aspects of the biomechanical weakening and strengthening effects in myopia and after scleral crosslinking, a comprehensive analysis of the underlying mechanical changes including the effect of vehicle injections is still missing. The purpose of this study was to provide a comprehensive analysis of biomechanical changes by scleral inflation testing in experimental myopia, after retrobulbar vehicle injections and scleral crosslinking using genipin in tree shrews. Our results suggest that biomechanical weakening in myopia involves an increased creep rate and higher strain levels at which collagen fibers uncrimp. Both weakening effects were reduced after scleral crosslinking using genipin at doses that were effective in slowing myopia progression. Vehicle injections increased mechanical hysteresis and had a small but significant effect on slowing myopia progression. Also, our results support scleral crosslinking as a potential treatment modality that can prevent or counteract scleral weakening effects in myopia. Furthermore, vehicle solutions may cause independent biomechanical effects, which should be considered when developing and evaluating scleral crosslinking procedures.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerótica / Tupaiidae / Iridoides / Modelos Animales de Enfermedad / Miopía Límite: Animals Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerótica / Tupaiidae / Iridoides / Modelos Animales de Enfermedad / Miopía Límite: Animals Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido